Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 20/20 | 0.81 |
| ▸ | ERBB2 | P04626 | 5/20 | 0.81 |
| ▸ | KIT | P10721 | 2/20 | 0.72 |
| ▸ | SRC | P12931 | 2/20 | 0.72 |
| ▸ | ERBB3 | P21860 | 2/20 | 0.72 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.72 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.72 |
| ▸ | CIT | O14578 | 1/20 | 0.72 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.72 |
| ▸ | GAK | O14976 | 1/20 | 0.72 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.72 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.72 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.72 |
| ▸ | STK17B | O94768 | 1/20 | 0.72 |
| ▸ | STK10 | O94804 | 1/20 | 0.72 |
| ▸ | ABL1 | P00519 | 1/20 | 0.72 |
| ▸ | LCK | P06239 | 1/20 | 0.72 |
| ▸ | FYN | P06241 | 1/20 | 0.72 |
| ▸ | YES1 | P07947 | 1/20 | 0.72 |
| ▸ | LYN | P07948 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2995071 | 0.90 | EGFR (1.00) | EGFRERBB2KITSRCERBB3 | |
| SCHEMBL3261578 | 0.90 | EGFR (0.84) | EGFRERBB2KITSRCERBB3 | |
| SCHEMBL29519908 | 0.90 | EGFR (1.00) | EGFRERBB2KITSRCERBB3 | |
| SCHEMBL2989664 | 0.90 | EGFR (1.00) | EGFRERBB2KITSRCERBB3 | |
| SCHEMBL25211674 | 0.87 | EGFR (0.79) | EGFRERBB2KITSRCERBB3 | |
| SCHEMBL30549063 | 0.87 | EGFR (0.79) | EGFRERBB2KITSRCERBB3 | |
| SCHEMBL25213338 | 0.86 | EGFR (0.78) | EGFRERBB2KITSRCERBB3 | |
| SCHEMBL26055531 | 0.86 | EGFR (0.85) | EGFRERBB2KITSRCERBB3 | |
| SCHEMBL25244129 | 0.86 | EGFR (0.78) | EGFRERBB2KITSRCERBB3 | |
| SCHEMBL30415948 | 0.86 | EGFR (0.88) | EGFRERBB2KITSRCERBB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100503580-C | Irreversible inhibitors of tyrosine kinases | WARNER LAMBERT CO (US) | 2009-06-24 | — | — | CN | disclosed |
| CN-1923818-A | Irreversible inhibitors of tyrosine kinases | WARNER LAMBERT CO (US) | 2007-03-07 | — | — | CN | disclosed |
| CN-1495172-A | Irreversible inhibitors of tyrosine kinases | ��ʲ | 2004-05-12 | — | — | CN | disclosed |
| CN-1145614-C | Irreversible inhibitors of tyrosine kinases, their pharmaceutical use and pharmaceutical compositions | ��ʲ | 2004-04-14 | — | — | CN | disclosed |
| CN-1218456-A | Irreversible inhibitors of tyrosine kinases | WARNER LAMBERT CO (US) | 1999-06-02 | — | — | CN | disclosed |