Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 11/20 | 0.51 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 8/20 | 0.46 |
| ▸ | ITK | Q08881 | 4/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2745372 | 0.93 | SYK (0.46) | SYKEGFRITK | |
| SCHEMBL2745715 | 0.85 | EGFR (0.60) | SYKEGFRITK | |
| SCHEMBL2746250 | 0.85 | SYK (0.57) | SYKGRM4EGFRITK | |
| SCHEMBL3997103 | 0.82 | SYK (0.55) | SYKGRM4EGFRITK | |
| SCHEMBL2746000 | 0.81 | SYK (0.67) | SYKEGFR | |
| SCHEMBL657079 | 0.81 | SYK (0.67) | SYKEGFRITK | |
| SCHEMBL656576 | 0.81 | SYK (0.67) | SYKEGFRITK | |
| SCHEMBL2745158 | 0.80 | SYK (0.58) | SYKEGFR | |
| SCHEMBL2746013 | 0.78 | SYK (0.57) | SYKEGFRITK | |
| SCHEMBL4004638 | 0.78 | JAK1 (0.57) | SYKEGFRITK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8178671-B2 | Ring attached at N2 and N4 of 2,4-pyrimidinediamines; for treating rheumatoid arthritis; N4-(2,2-dimethyl-3-oxo-4H-5-pyrid[1,4]oxazin-6-yl)-5-fluoro-N2-(3,4,5-trimethoxyphenyl)-2,4-pyrimidinediamine | RIGEL PHARMACEUTICALS, INC. (US) | 2012-05-15 | — | — | US | claimed |