Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 15/20 | 0.57 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.45 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | ITK | Q08881 | 1/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.40 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.40 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2746250 | 0.93 | SYK (0.57) | SYKPRKCQEGFRITK | |
| SCHEMBL2745372 | 0.85 | SYK (0.46) | SYKCYP11B1CYP11B2EGFRITK | |
| SCHEMBL2746014 | 0.85 | SYK (0.63) | SYKPRKCQEGFRITK | |
| SCHEMBL2745316 | 0.81 | SYK (0.59) | SYKPRKCQCYP11B1CYP11B2EGFR | |
| SCHEMBL656711 | 0.81 | SYK (0.64) | SYKAURKA | |
| SCHEMBL16660512 | 0.81 | SYK (0.64) | SYKAURKA | |
| SCHEMBL2745756 | 0.80 | SYK (0.64) | SYKPRKCQEGFRITK | |
| SCHEMBL2745476 | 0.80 | SYK (0.67) | SYKPRKCQEGFRAURKA | |
| SCHEMBL2745583 | 0.78 | SYK (0.51) | SYKEGFRITK | |
| SCHEMBL2745994 | 0.78 | SYK (0.75) | SYKPRKCQEGFRITKAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8178671-B2 | Ring attached at N2 and N4 of 2,4-pyrimidinediamines; for treating rheumatoid arthritis; N4-(2,2-dimethyl-3-oxo-4H-5-pyrid[1,4]oxazin-6-yl)-5-fluoro-N2-(3,4,5-trimethoxyphenyl)-2,4-pyrimidinediamine | RIGEL PHARMACEUTICALS, INC. (US) | 2012-05-15 | — | — | US | claimed |