Quinoline

Quinoline

SCHEMBL27458348

CCCCCn1nccc1N.c1ccc2ncccc2c1

nearest known ligand 0.45

Full drug profile on Sugi Atlas →

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.45
TLR8 Q9NR97 10/20 0.44
SLC9A1 P19634 4/20 0.43
MPO P05164 2/20 0.39
MEN1 O00255 1/20 0.39
CYP1A2 P05177 1/20 0.39
CYP2C9 P11712 1/20 0.39
CRHBP P24387 1/20 0.39
CYP2C19 P33261 1/20 0.39
KMT2A Q03164 1/20 0.39
CRHR2 Q13324 1/20 0.39
GRK6 P43250 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL438493 0.83 KDM4E (0.46) ALDH1A1TLR8SLC9A1MPO
SCHEMBL15189572 0.81 KDM4E (0.44) ALDH1A1TLR8SLC9A1
Quinoline SCHEMBL28025239 0.80 ALDH1A1 (0.71) ALDH1A1TLR8MEN1CYP1A2CYP2C19
Quinoline SCHEMBL28202501 0.78 ALDH1A1 (0.68) ALDH1A1TLR8MEN1CYP1A2CYP2C19
Decane SCHEMBL9763188 0.78 ALDH1A1 (0.68) ALDH1A1TLR8
Quinoline SCHEMBL27417695 0.78 ALDH1A1 (0.68) ALDH1A1TLR8
Dodecane SCHEMBL28937946 0.78 ALDH1A1 (0.68) ALDH1A1TLR8
SCHEMBL10725199 0.78 KDM4E (0.47) ALDH1A1TLR8SLC9A1MPOCYP1A2
Quinoline SCHEMBL27987363 0.78 ALDH1A1 (0.68) ALDH1A1TLR8
Quinoline SCHEMBL28806682 0.77 ALDH1A1 (0.49) ALDH1A1TLR8SLC9A1MPOMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1129236-A Active dye and preparation method and usage thereof CIBA GEIGY AG (CH) 1996-08-21 CN claimed