SCHEMBL27458596

SCHEMBL27458596

CS(=O)(=O)c1cnc(C(=O)Nc2nccc(N3CCC(F)(F)CC3)n2)c(N2CCC3(CC2)CC3)c1

nearest known ligand 0.53

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
▸ KIF18A Q8NI77 20/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30953917 1.00 KIF18A (0.53) KIF18A
SCHEMBL27455288 0.88 KIF18A (0.65) KIF18A
SCHEMBL30953952 0.88 KIF18A (0.65) KIF18A
SCHEMBL27458275 0.85 SCN10A (0.45) KIF18A
SCHEMBL30953918 0.85 SCN10A (0.45) KIF18A
SCHEMBL27458582 0.85 KIF18A (0.44) KIF18A
SCHEMBL30953977 0.85 KIF18A (0.44) KIF18A
SCHEMBL30953949 0.82 KIF18A (0.67) KIF18A
SCHEMBL27456495 0.82 KIF18A (0.67) KIF18A
SCHEMBL30953942 0.79 KIF18A (0.71) KIF18A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024137984-A1 INHIBITORS OF KIF18A AND USES THEREOF ACCENT THERAPEUTICS, INC. (US) 2024-06-27 — — WO disclosed
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