Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | CKS1B | P61024 | 1/20 | 0.36 |
| ▸ | SKP1 | P63208 | 1/20 | 0.36 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | USP1 | O94782 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27458686 | 0.85 | NR1H2 (0.41) | MAPTESR2NR1H2CYP11B2PIK3CD | |
| SCHEMBL27458695 | 0.85 | MAPT (0.42) | MAPTESR2NR1H2CYP11B2CKS1B | |
| SCHEMBL30954006 | 0.85 | NR1H2 (0.41) | MAPTESR2NR1H2CYP11B2PIK3CD | |
| SCHEMBL14380649 | 0.80 | ESR2 (0.44) | MAPTESR2NR1H2GPR119GRM5 | |
| SCHEMBL30513283 | 0.80 | CYP11B2 (0.41) | MAPTESR2NR1H2CYP11B2GPR119 | |
| SCHEMBL10053887 | 0.78 | CYP11B2 (0.45) | MAPTESR2NR1H2CYP11B2CHRM4 | |
| SCHEMBL31073472 | 0.76 | MAPT (0.55) | MAPTESR2NR1H2CCNA2CDK2 | |
| SCHEMBL27097490 | 0.76 | CHRM4 (0.43) | MAPTESR2NR1H2DHODHGPR119 | |
| SCHEMBL2964825 | 0.75 | CYP11B2 (0.42) | ESR2NR1H2CYP11B2CHRM4DRD2 | |
| SCHEMBL30462275 | 0.74 | POLB (0.47) | MAPTESR2NR1H2CYP11B2GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024137984-A1 | INHIBITORS OF KIF18A AND USES THEREOF | ACCENT THERAPEUTICS, INC. (US) | 2024-06-27 | — | — | WO | disclosed |