Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 10/20 | 0.63 |
| ▸ | EGFR | P00533 | 7/20 | 0.53 |
| ▸ | ITK | Q08881 | 3/20 | 0.53 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.48 |
| ▸ | CSF1R | P07333 | 2/20 | 0.44 |
| ▸ | CDK4 | P11802 | 2/20 | 0.44 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.44 |
| ▸ | BTK | Q06187 | 1/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2745756 | 0.94 | SYK (0.64) | SYKEGFRITKPRKCQBTK | |
| SCHEMBL2745994 | 0.93 | SYK (0.75) | SYKEGFRITKPRKCQBTK | |
| SCHEMBL2745861 | 0.86 | SYK (0.77) | SYKEGFRITKPRKCQBTK | |
| SCHEMBL2746013 | 0.85 | SYK (0.57) | SYKEGFRITKPRKCQ | |
| SCHEMBL1198121 | 0.81 | EGFR (0.61) | SYKEGFRITKBTK | |
| SCHEMBL2745688 | 0.81 | SYK (0.65) | SYKEGFRPRKCQ | |
| SCHEMBL2746250 | 0.80 | SYK (0.57) | SYKEGFRITKPRKCQ | |
| SCHEMBL2745715 | 0.78 | EGFR (0.60) | SYKEGFRITKBTK | |
| SCHEMBL2745934 | 0.78 | SYK (0.63) | SYKEGFRITKPRKCQ | |
| SCHEMBL654534 | 0.78 | SYK (1.00) | SYKEGFRPRKCQBTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8178671-B2 | Ring attached at N2 and N4 of 2,4-pyrimidinediamines; for treating rheumatoid arthritis; N4-(2,2-dimethyl-3-oxo-4H-5-pyrid[1,4]oxazin-6-yl)-5-fluoro-N2-(3,4,5-trimethoxyphenyl)-2,4-pyrimidinediamine | RIGEL PHARMACEUTICALS, INC. (US) | 2012-05-15 | — | — | US | claimed |