Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | APEX1 | P27695 | 1/20 | 0.44 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.44 |
| ▸ | AKT1 | P31749 | 1/20 | 0.34 |
| ▸ | AKT2 | P31751 | 1/20 | 0.34 |
| ▸ | NOS2 | P35228 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30854860 | 0.92 | — | — | |
| Pivalate SCHEMBL28031626 | 0.77 | KCNH2 (0.35) | KCNH2LMNAAPEX1PMP22AKT1 | |
| Methylamine SCHEMBL27463181 | 0.70 | LMNA (0.52) | KCNH2LMNAAPEX1PMP22AKT1 | |
| SCHEMBL6344963 | 0.67 | — | — | |
| SCHEMBL19325388 | 0.65 | — | — | |
| SCHEMBL31247589 | 0.65 | — | — | |
| SCHEMBL481994 | 0.64 | AKT2 (0.61) | AKT1AKT2ALDH1A1 | |
| Fomepizole SCHEMBL20769777 | 0.63 | KCNH2 (1.00) | KCNH2LMNAAPEX1PMP22AKT1 | |
| SCHEMBL27843059 | 0.63 | LMNA (0.50) | KCNH2LMNAAPEX1PMP22AKT1 | |
| Hydrochloric Acid SCHEMBL4562672 | 0.63 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101142217-B | Imidazopyridazine compounds | LILLY CO ELI | 2010-12-08 | — | — | CN | disclosed |
| CN-101142217-A | Imidazopyridazine compounds | LILLY CO ELI (US) | 2008-03-12 | — | — | CN | disclosed |
| CN-1126994-A | Novel (1-heteroazolyl-1-heterocyclyl) alkane derivatives and their use as neuroprotective agents | ASTRA AB (SE) | 1996-07-17 | — | — | CN | disclosed |