Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.41 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.41 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6548166 | 0.84 | KDM4E (0.40) | KDM4EPDCD1CD274CYP2A6CYP2B6 | |
| SCHEMBL309416 | 0.82 | KDM4E (0.45) | KDM4EPDCD1CD274CYP2A6CYP2B6 | |
| SCHEMBL1588208 | 0.82 | KDM4E (0.41) | KDM4EPDCD1CD274CYP2A6CYP2B6 | |
| SCHEMBL30404870 | 0.82 | KDM4E (0.45) | KDM4EPDCD1CD274CYP2A6CYP2B6 | |
| SCHEMBL27884523 | 0.77 | KDM4E (0.41) | KDM4EPDCD1CD274CYP2A6CYP2B6 | |
| SCHEMBL1610471 | 0.77 | CYP2A6 (0.45) | CYP2A6ALDH1A1TSHRCA1CA2 | |
| SCHEMBL30612770 | 0.74 | CA12 (0.54) | KDM4EPDCD1CD274CYP2A6CYP2B6 | |
| SCHEMBL29706107 | 0.74 | ESR2 (0.54) | KDM4EPDCD1CD274CYP2A6CYP2B6 | |
| SCHEMBL616 | 0.74 | ESR2 (0.54) | KDM4EPDCD1CD274CYP2A6CYP2B6 | |
| SCHEMBL7912257 | 0.73 | NR1H2 (0.45) | KDM4EPDCD1CD274ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1158269-C | 4-aminothiazole derivs, their preparation and their use as inhibitors of cyclin-dependent kinases | ������ҩ������˾ | 2004-07-21 | — | — | CN | disclosed |
| CN-1276789-A | 4-aminothiazole derivatives, their preparation and their use as inhibitors of cyclin dependent kinases | AGOURON PHARMA (US) | 2000-12-13 | — | — | CN | disclosed |