Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.40 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.39 |
| ▸ | MYC | P01106 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30404870 | 1.00 | KDM4E (0.45) | KDM4EALDH1A1TSHRRAB9AMEN1 | |
| Biphenyl SCHEMBL2455099 | 0.85 | ALDH1A1 (0.48) | KDM4EALDH1A1TSHRRAB9AMEN1 | |
| SCHEMBL954787 | 0.85 | MEN1 (0.53) | ALDH1A1RAB9AMEN1KMT2APTGS2 | |
| SCHEMBL15676174 | 0.84 | BRD4 (0.42) | ALDH1A1TSHRRAB9AMEN1KMT2A | |
| SCHEMBL1830917 | 0.83 | ALDH1A1 (0.46) | KDM4EALDH1A1TSHRRAB9AMEN1 | |
| SCHEMBL14840347 | 0.83 | ERN1 (0.49) | ALDH1A1TSHRRAB9ACA12CA1 | |
| SCHEMBL8357733 | 0.83 | CA12 (0.39) | KDM4EALDH1A1TSHRRAB9AMEN1 | |
| SCHEMBL27463129 | 0.82 | KDM4E (0.42) | KDM4EALDH1A1TSHRRAB9ACA12 | |
| SCHEMBL7092661 | 0.81 | ALDH1A1 (0.44) | KDM4EALDH1A1RAB9AMEN1KMT2A | |
| SCHEMBL3975312 | 0.81 | BRD9 (0.37) | KDM4EALDH1A1TSHRRAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 53 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10351506-B2 | Purified plasticizers, production and use | EXXONMOBIL CHEMICAL PATENTS INC. (US) | 2019-07-16 | — | — | US | disclosed |
| US-20190031593-A1 | Purified Plasticizers, Production and Use | EXXONMOBIL CHEMICAL PATENTS INC. | 2019-01-31 | — | — | US | disclosed |
| EP-2386547-B1 | Multicyclic amino acid derivatives and methods of their use | LEXICON PHARMACEUTICALS INC (US) | 2018-06-20 | — | — | EP | disclosed |
| US-8629156-B2 | Tryptophan hydroxylase inhibitors | LEXICON PHARMACEUTICALS, INC. (US) | 2014-01-14 | — | — | US | disclosed |
| US-20130274261-A1 | METHODS FOR TREATING PULMONARY HYPERTENSION | LEXICON PHARMACEUTICALS, INC. | 2013-10-17 | — | — | US | disclosed |
| US-20130137635-A1 | TRYPTOPHAN HYDROXYLASE INHIBITORS FOR THE TREATMENT OF METASTATIC BONE DISEASE | LEXICON PHARMACEUTICALS, INC. (US) | 2013-05-30 | — | — | US | disclosed |
| US-8410121-B2 | Methods of treating pulmonary hypertension | LEXICON PHARMACEUTICALS, INC. (US) | 2013-04-02 | — | — | US | disclosed |
| EP-2533778-A1 | TRYPTOPHAN HYDROXYLASE INHIBITORS FOR THE TREATMENT OF METASTATIC BONE DISEASE | Lexicon Pharmaceuticals, Inc. (US) | 2012-12-19 | — | — | EP | disclosed |
| US-20120316171-A1 | Tryptophan Hydroxylase Inhibitors for the Treatment of Cancer | LEXICON PHARMACEUTICALS, INC. | 2012-12-13 | — | — | US | disclosed |
| CN-102753168-A | Tryptophan hydroxylase inhibitors for the treatment of metastatic bone disease | LEXICON PHARMACEUTICALS INC | 2012-10-24 | — | — | CN | disclosed |
| WO-2009002964-A1 | METHODS OF TREATING SEROTONIN-MEDIATED DISEASES AND DISORDERS | LEXICON PHARMACEUTICALS, INC. (US) | 2008-12-31 | — | — | WO | disclosed |
| EP-1984344-A2 | MULTICYCLIC AMINO ACID DERIVATIVES AND METHODS OF THEIR USE | Lexicon Pharmaceuticals, Inc. (US) | 2008-10-29 | — | — | EP | disclosed |
| US-20070191370-A1 | Multicyclic amino acid derivatives and methods of their use | TERSERA THERAPEUTICS LLC | 2007-08-16 | — | — | US | disclosed |
| WO-2007089335-A2 | MULTICYCLIC AMINO ACID DERIVATIVES AND METHODS OF THEIR USE | LEXICON PHARMACEUTICAL INC. (US) | 2007-08-09 | — | — | WO | disclosed |
| EP-1425015-A4 | TETRAHYDROQUINOLINE DERIVATIVES AS ANTITHROMBOTIC AGENTS | BRISTOL MYERS SQUIBB CO (US) | 2004-12-15 | — | — | EP | disclosed |
| EP-1425015-A2 | TETRAHYDROQUINOLINE DERIVATIVES AS ANTITHROMBOTIC AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-06-09 | — | — | EP | disclosed |
| EP-1055660-B1 | Process for producing highly pure aromatic polycarboxylic acid | MITSUBISHI GAS CHEMICAL CO (JP) | 2003-05-21 | — | — | EP | disclosed |
| WO-2003015715-A2 | TETRAHYDROQUINOLINE DERIVATIVES AS ANTITHROMBOTIC AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2003-02-27 | — | — | WO | disclosed |
| US-6452047-B1 | LOW COLOR, SIMPLE PURIFICATION OF SUCH AS 2,6-NAPHTHALENE-DICARBOXYLIC ACID OR 4,4'-BIPHENYLDICARBOXYLIC ACID; AMINE SALT FORMATION, PRECIPITATION, AND DECOMPOSITION OF SALT BY DISSOLUTION IN WATER | MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) | 2002-09-17 | — | — | US | disclosed |
| EP-1055660-A1 | Process for producing highly pure aromatic polycarboxylic acid | MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) | 2000-11-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130274261-A1 | METHODS FOR TREATING PULMONARY HYPERTENSION | TPH1, TPH2, PTGIS | KDM4E 2484/4885ALDH1A1 602/4885TSHR 2562/4885 |
| US-10351506-B2 | Purified plasticizers, production and use | ALKBH3, FTO, ALK | KDM4E 110/4885ALDH1A1 142/4885TSHR 2624/4885 |
| US-20120316171-A1 | Tryptophan Hydroxylase Inhibitors for the Treatment of Cancer | TPH1, TPH2, HNMT | KDM4E 795/4885ALDH1A1 478/4885TSHR 772/4885 |
| US-20190031593-A1 | Purified Plasticizers, Production and Use | ALKBH3, FTO, ALK | KDM4E 110/4885ALDH1A1 142/4885TSHR 2624/4885 |
| US-20070191370-A1 | Multicyclic amino acid derivatives and methods of their use | AADAT, HNMT, TPH1 | KDM4E 4376/4885ALDH1A1 1286/4885TSHR 1704/4885 |
| US-20130137635-A1 | TRYPTOPHAN HYDROXYLASE INHIBITORS FOR THE TREATMENT OF METASTATIC BONE DISEASE | TPH1, TPH2, IDO1 | KDM4E 445/4885ALDH1A1 1242/4885TSHR 1342/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.