Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.43 |
| ▸ | GCK | P35557 | 12/20 | 0.37 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.36 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27466710 | 0.91 | KCNH2 (0.50) | RAB9ANPC1SMN1; SMN2ALDH1A1KCNH2 | |
| SCHEMBL27482043 | 0.88 | SMN1; SMN2 (0.43) | RAB9ANPC1SMN1; SMN2ALDH1A1KCNH2 | |
| SCHEMBL2646610 | 0.82 | KCNH2 (0.55) | RAB9ANPC1SMN1; SMN2ALDH1A1KCNH2 | |
| SCHEMBL2645843 | 0.82 | KCNH2 (0.55) | RAB9ANPC1SMN1; SMN2ALDH1A1KCNH2 | |
| SCHEMBL27483469 | 0.81 | KCNH2 (0.51) | RAB9ANPC1SMN1; SMN2KCNH2GCK | |
| SCHEMBL2645916 | 0.81 | KCNH2 (0.60) | RAB9ANPC1SMN1; SMN2ALDH1A1KCNH2 | |
| SCHEMBL2658443 | 0.81 | KCNH2 (0.60) | RAB9ANPC1SMN1; SMN2ALDH1A1KCNH2 | |
| SCHEMBL27465638 | 0.81 | GCK (0.60) | KCNH2GCK | |
| SCHEMBL27482381 | 0.80 | KCNH2 (0.35) | RAB9ANPC1KCNH2GCK | |
| SCHEMBL27482390 | 0.79 | PTGS1 (0.35) | RAB9ANPC1KCNH2GCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1151140-C | Glucokinase activators | - | 2004-05-26 | — | — | CN | claimed |
| CN-1349519-A | Glucokinase activators | HOFFMANN LA ROCHE (CH) | 2002-05-15 | — | — | CN | claimed |
| CN-1151140-C | Glucokinase activators | - | 2004-05-26 | — | — | CN | disclosed |
| CN-1349519-A | Glucokinase activators | HOFFMANN LA ROCHE (CH) | 2002-05-15 | — | — | CN | disclosed |