Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 14/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.59 |
| ▸ | FFAR2 | O15552 | 2/20 | 0.58 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27467150 | 0.89 | FFAR2 (0.63) | GCKKCNH2FFAR2EPHX2 | |
| SCHEMBL27482753 | 0.89 | GCK (0.60) | GCKKCNH2FFAR2EPHX2POLB | |
| SCHEMBL27466236 | 0.88 | GCK (0.59) | GCKKCNH2FFAR2EPHX2POLB | |
| SCHEMBL27468583 | 0.87 | KCNH2 (0.59) | GCKKCNH2FFAR2EPHX2POLB | |
| SCHEMBL27548020 | 0.86 | KCNH2 (0.58) | GCKKCNH2FFAR2EPHX2POLB | |
| SCHEMBL27548010 | 0.86 | GCK (0.59) | GCKKCNH2FFAR2EPHX2POLB | |
| SCHEMBL27480871 | 0.85 | GCK (0.69) | GCKKCNH2FFAR2EPHX2POLB | |
| SCHEMBL27481667 | 0.85 | GCK (0.69) | GCKKCNH2FFAR2EPHX2POLB | |
| SCHEMBL27548009 | 0.84 | GCK (0.68) | GCKKCNH2FFAR2EPHX2POLB | |
| SCHEMBL2645871 | 0.82 | GCK (0.74) | GCKKCNH2FFAR2EPHX2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1151140-C | Glucokinase activators | - | 2004-05-26 | — | — | CN | claimed |
| CN-1349519-A | Glucokinase activators | HOFFMANN LA ROCHE (CH) | 2002-05-15 | — | — | CN | claimed |
| CN-1151140-C | Glucokinase activators | - | 2004-05-26 | — | — | CN | disclosed |
| CN-1349519-A | Glucokinase activators | HOFFMANN LA ROCHE (CH) | 2002-05-15 | — | — | CN | disclosed |