SCHEMBL27466258

SCHEMBL27466258

ClCc1ccc(-c2ccccc2)c(-c2nnn[nH]2)c1

nearest known ligand 0.36

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
CSNK2A1 P68400 2/20 0.36
FOLH1 Q04609 1/20 0.33
BACE1 P56817 1/20 0.31
DCUN1D2 Q6PH85 1/20 0.31
DCUN1D1 Q96GG9 1/20 0.31
PTPN2 P17706 1/20 0.31
PTPN1 P18031 1/20 0.31
PTPN6 P29350 1/20 0.31
ALDH1A1 P00352 1/20 0.30
LMNA P02545 1/20 0.30
METAP2 P50579 1/20 0.30
TTR P02766 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1774163 0.87 FOLH1 (0.37) CSNK2A1FOLH1BACE1PTPN2PTPN1
SCHEMBL596244 0.86 CSNK2A1 (0.49) CSNK2A1FOLH1BACE1DCUN1D2DCUN1D1
SCHEMBL8674236 0.86 FOLH1 (0.33) CSNK2A1FOLH1BACE1DCUN1D2DCUN1D1
SCHEMBL27259186 0.85 CSNK2A1 (0.33) CSNK2A1FOLH1
Hydrochloric Acid SCHEMBL1131262 0.84 CSNK2A1 (0.50) CSNK2A1FOLH1BACE1LMNA
SCHEMBL6962635 0.84 AKT1 (0.36) DCUN1D2DCUN1D1
SCHEMBL27452763 0.83 TDP1 (0.36) CSNK2A1FOLH1BACE1DCUN1D2DCUN1D1
SCHEMBL594529 0.79 MAPT (0.35) ALDH1A1LMNA
SCHEMBL29034386 0.78 DCUN1D1 (0.45) DCUN1D2DCUN1D1ALDH1A1LMNAMETAP2
SCHEMBL29499607 0.78 DCUN1D1 (0.47) DCUN1D2DCUN1D1ALDH1A1LMNAMETAP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1140450-A Potassium salts of biphenylmethane derivatives and medicaments containing them WAKUNAGA SEIYAKU KK (JP) 1997-01-15 CN disclosed