Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 12/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 12/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 12/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | MLNR | O43193 | 1/20 | 0.34 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | FYN | P06241 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2090139 | 0.88 | SLC6A2 (0.41) | SLC6A2SLC6A4SLC6A3CYP1A2 | |
| SCHEMBL3817537 | 0.84 | — | — | |
| SCHEMBL27876252 | 0.83 | SLC6A2 (0.37) | SLC6A2SLC6A4SLC6A3CYP2D6MEN1 | |
| SCHEMBL20537294 | 0.82 | SLC6A2 (0.36) | SLC6A2SLC6A4SLC6A3CYP2D6MEN1 | |
| SCHEMBL3390986 | 0.80 | PRCP (0.41) | SLC6A2SLC6A4SLC6A3TSHR | |
| SCHEMBL447293 | 0.77 | — | — | |
| SCHEMBL18735782 | 0.75 | SLC6A2 (0.38) | SLC6A2SLC6A4SLC6A3CYP2D6MEN1 | |
| SCHEMBL14032382 | 0.72 | SLC6A2 (0.36) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL1515328 | 0.72 | — | — | |
| SCHEMBL14782700 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1252065-C | Cinnoline compounds | ASTRAZENECA AB (SE) | 2006-04-19 | — | — | CN | disclosed |
| CN-1245402-C | indole derivatives, process for their preparation, pharmaceutical compositions containing them and their use | ASTRAZENECA AB (SE) | 2006-03-15 | — | — | CN | disclosed |
| CN-1167422-C | Quinazoline derivatives as angiogenesis inhibitors | — | 2004-09-22 | — | — | CN | disclosed |
| CN-1468230-A | Compound (I) | — | 2004-01-14 | — | — | CN | disclosed |
| CN-1446214-A | Cinnoline compounds | ASTRAZENECA AB (SE) | 2003-10-01 | — | — | CN | disclosed |
| CN-1346271-A | Quinazoline derivatives as angiogenesis inhibitors | ASTRAZENECA UK LTD (SE) | 2002-04-24 | — | — | CN | disclosed |