Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 17/20 | 0.64 |
| ▸ | EDNRB | P24530 | 16/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | NMT1 | P30419 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7217576 | 0.86 | EDNRA (0.72) | EDNRAEDNRBMEN1CYP2C9TSHR | |
| SCHEMBL27548687 | 0.85 | EDNRA (0.73) | EDNRAEDNRB | |
| SCHEMBL6151080 | 0.85 | EDNRA (0.84) | EDNRAEDNRBTSHR | |
| SCHEMBL7337147 | 0.84 | EDNRA (0.82) | EDNRAEDNRBTSHR | |
| SCHEMBL7337145 | 0.82 | EDNRA (0.80) | EDNRAEDNRBTSHR | |
| SCHEMBL6151470 | 0.80 | EDNRA (0.70) | EDNRAEDNRB | |
| SCHEMBL9064490 | 0.79 | EDNRA (1.00) | EDNRAEDNRB | |
| SCHEMBL7232444 | 0.79 | EDNRA (1.00) | EDNRAEDNRB | |
| SCHEMBL27452917 | 0.78 | EDNRB (0.72) | EDNRAEDNRB | |
| SCHEMBL27467617 | 0.78 | EDNRB (0.71) | EDNRAEDNRBNMT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1130355-C | Thienyl-, Furyl-, Pyrrolyl- and biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin | TEXAS BIOTECHNOLOGY CORP (US) | 2003-12-10 | — | — | CN | disclosed |
| CN-1184470-A | Thienyl-, Furyl-, Pyrrolyl- and biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin | TEXAS BIOTECHNOLOGY CORP (US) | 1998-06-10 | — | — | CN | disclosed |