Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 5/20 | 0.41 |
| ▸ | EDNRB | P24530 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.37 |
| ▸ | HPGD | P15428 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | ME2 | P23368 | 1/20 | 0.36 |
| ▸ | ME1 | P48163 | 1/20 | 0.36 |
| ▸ | ME3 | Q16798 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27467952 | 0.85 | GSK3B (0.35) | KDM4ELMNAMAPTPTGS2 | |
| SCHEMBL27467953 | 0.85 | HRH3 (0.33) | — | |
| SCHEMBL27466572 | 0.82 | PTGS2 (0.38) | ALDH1A1PTGS2 | |
| SCHEMBL27465491 | 0.81 | KMT2A (0.36) | LMNAMAPT | |
| SCHEMBL286649 | 0.80 | ESR2 (0.50) | EDNRAEDNRBALDH1A1HPGDKDM4E | |
| SCHEMBL1419877 | 0.80 | ESR2 (0.50) | EDNRAEDNRBALDH1A1HPGDKDM4E | |
| SCHEMBL27485885 | 0.80 | PTGS2 (0.36) | PTGS2 | |
| SCHEMBL27467950 | 0.80 | PDE3B (0.33) | — | |
| SCHEMBL7897258 | 0.79 | PTGS2 (0.41) | HPGDMAPTPTGS2 | |
| SCHEMBL12188829 | 0.79 | PTGS2 (0.41) | HPGDMAPTPTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1166658-C | 4,5 diaryl-3 (2H) -furanone derivatives as cyclooxygenase-2 inhibitors | ��ʽ����̫ƽ�� | 2004-09-15 | — | — | CN | disclosed |
| CN-1348447-A | 4,5 diaryl-3 (2H) -furanone derivatives as cyclooxygenase-2 inhibitors | PACIFIC CORP (KR) | 2002-05-08 | — | — | CN | disclosed |