Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 8/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 8/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 2/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | GCK | P35557 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27466734 | 0.89 | HDAC8 (0.38) | SLC6A4SLC6A3HDAC8HDAC6HDAC1 | |
| SCHEMBL28770995 | 0.83 | HDAC8 (0.38) | SLC6A4SLC6A3HDAC8HDAC6HDAC1 | |
| SCHEMBL27483135 | 0.81 | HDAC8 (0.41) | SLC6A3HDAC8HDAC6HDAC1 | |
| SCHEMBL27482760 | 0.80 | HPGD (0.33) | SLC6A4SLC6A3HDAC8HDAC6HDAC1 | |
| SCHEMBL27467155 | 0.79 | MDM2 (0.40) | SLC6A3 | |
| SCHEMBL27466234 | 0.77 | GCK (0.33) | SLC6A4SLC6A3HDAC8HDAC6HDAC1 | |
| SCHEMBL27466732 | 0.77 | HDAC8 (0.41) | SLC6A4SLC6A3HDAC8HDAC6HDAC1 | |
| SCHEMBL27504948 | 0.77 | HDAC8 (0.38) | SLC6A4SLC6A3HDAC8HDAC6HDAC1 | |
| SCHEMBL27515302 | 0.76 | HDAC8 (0.41) | SLC6A4SLC6A3HDAC8HDAC6HDAC1 | |
| SCHEMBL28770994 | 0.74 | SLC18A3 (0.42) | SLC6A4SLC6A3KCNH2GCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1151140-C | Glucokinase activators | - | 2004-05-26 | — | — | CN | disclosed |
| CN-1349519-A | Glucokinase activators | HOFFMANN LA ROCHE (CH) | 2002-05-15 | — | — | CN | disclosed |