Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 10/20 | 0.70 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ammonia Solution, Strong SCHEMBL27449843 | 0.97 | PDE5A (0.66) | PDE5AMAPTHPGDSMN1; SMN2NPC1 | |
| SCHEMBL6597241 | 0.82 | PDE5A (1.00) | PDE5A | |
| SCHEMBL7918154 | 0.80 | PDE5A (0.92) | PDE5A | |
| SCHEMBL27468605 | 0.80 | PDE5A (0.51) | PDE5ASMN1; SMN2CYP1A2CYP2C19 | |
| SCHEMBL27449842 | 0.80 | PDE5A (0.48) | PDE5ASMN1; SMN2CYP1A2CYP2C19LMNA | |
| Ammonia Solution, Strong SCHEMBL27466741 | 0.76 | PDE5A (0.60) | PDE5AMAPTSMN1; SMN2LMNATDP1 | |
| SCHEMBL29435299 | 0.74 | MAPT (0.67) | PDE5AMAPTHPGDSMN1; SMN2NPC1 | |
| SCHEMBL512092 | 0.74 | MAPT (0.67) | PDE5AMAPTHPGDSMN1; SMN2NPC1 | |
| SCHEMBL6595421 | 0.73 | PDE5A (0.47) | PDE5AHPGDSMN1; SMN2MEN1KMT2A | |
| SCHEMBL27543491 | 0.73 | PDE5A (0.45) | PDE5AMAPTSMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1151136-C | Condensed pyridazine compound | ������������ʽ���� | 2004-05-26 | — | — | CN | disclosed |
| CN-1135210-A | Fused pyridazine compound | EISAI CO LTD (JP) | 1996-11-06 | — | — | CN | disclosed |