SCHEMBL27469790

SCHEMBL27469790

CC(NC(=O)OC(C)(C)C)C(=O)N1CCC2(CC2)C(F)(F)C1

nearest known ligand 0.37

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
HRH2 P25021 2/20 0.37
HRH1 P35367 2/20 0.37
PREP P48147 1/20 0.37
CTSL P07711 3/20 0.36
CTSK P43235 2/20 0.36
CTSB P07858 1/20 0.36
CA1 P00915 1/20 0.35
CA2 P00918 1/20 0.35
CA7 P43166 1/20 0.35
KMT2A Q03164 2/20 0.34
HDAC8 Q9BY41 1/20 0.33
MEN1 O00255 1/20 0.33
TSHR P16473 3/20 0.33
ALOX15 P16050 1/20 0.33
CYP2D6 P10635 1/20 0.32
ELANE P08246 1/20 0.32
GLS O94925 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14737817 0.81 CA1 (0.41) HRH2HRH1PREPCTSLCTSK
SCHEMBL27469778 0.78 CYP1A2 (0.43) HRH2HRH1PREPCTSLCTSK
SCHEMBL30644456 0.78 CA1 (0.40) HRH2HRH1PREPCTSLCTSK
SCHEMBL18212467 0.78 CYP1A2 (0.43) HRH2HRH1PREPCTSLCTSK
SCHEMBL30644499 0.78 CA1 (0.40) HRH2HRH1PREPCTSLCTSK
SCHEMBL1604637 0.78 USP2 (0.44)
SCHEMBL18212464 0.76 CYP2C9 (0.44) HRH2HRH1PREPCTSLCTSK
SCHEMBL27470196 0.76 CYP1A2 (0.44) HRH2HRH1PREPCTSLCTSK
SCHEMBL31555894 0.76 CTSK (0.41) HRH2HRH1CTSLCTSKCTSB
SCHEMBL21981480 0.75 CYP2C9 (0.40) HRH2HRH1PREPCTSLCTSK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4618978-A1 COMPOUNDS, COMPOSITIONS, AND METHODS Tenvie Therapeutics Inc. (US) 2025-09-24 EP disclosed
WO-2024108147-A1 COMPOUNDS, COMPOSITIONS, AND METHODS DENALI THERAPEUTICS INC. (US) 2024-05-23 WO disclosed
WO-2024108147-A1 COMPOUNDS, COMPOSITIONS, AND METHODS DENALI THERAPEUTICS INC. (US) 2024-05-23 WO disclosed