Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.34 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.34 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.34 |
| ▸ | GRIK1 | P39086 | 3/20 | 0.34 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.34 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.34 |
| ▸ | GRIK3 | Q13003 | 2/20 | 0.34 |
| ▸ | GRIK5 | Q16478 | 2/20 | 0.34 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.34 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.34 |
| ▸ | LTA4H | P09960 | 1/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 2-Oxoisovalerate SCHEMBL1462512 | 0.85 | TP53 (0.41) | SLC7A5TP53CYP2D6CYP2C19 | |
| 2-Oxoisovalerate SCHEMBL30552298 | 0.85 | — | — | |
| 2-Oxoisovalerate SCHEMBL42329 | 0.85 | — | — | |
| 2-Oxoisovalerate SCHEMBL8417263 | 0.82 | SLC7A5 (0.71) | SLC7A5TP53SLC1A3SLC1A2SLC1A1 | |
| 2-Oxoisovalerate SCHEMBL22070188 | 0.82 | SLC7A5 (0.71) | SLC7A5TP53SLC1A3SLC1A2SLC1A1 | |
| 2-Oxoisovalerate SCHEMBL8417262 | 0.82 | SLC7A5 (0.71) | SLC7A5TP53SLC1A3SLC1A2SLC1A1 | |
| 2-Oxoisovalerate SCHEMBL468254 | 0.82 | — | — | |
| Alanine SCHEMBL4256723 | 0.82 | SLC7A5 (0.53) | SLC7A5TP53SLC1A3SLC1A2SLC1A1 | |
| 2-Oxoisovalerate SCHEMBL7277489 | 0.82 | — | — | |
| Alanine SCHEMBL4256720 | 0.82 | SLC7A5 (0.53) | SLC7A5TP53SLC1A3SLC1A2SLC1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3223834-B2 | PROBIOTIC AND PREBIOTIC COMPOSITIONS COMPRISING BLAUTIA SPECIES FOR REDUCING INFLAMMATION | EVELO BIOSCIENCES INC (US) | 2023-07-12 | — | — | EP | disclosed |
| US-11672834-B2 | Probiotic and prebiotic compositions, and methods of use thereof for modulation of the microbiome | EVELO BIOSCIENCES, INC. (US) | 2023-06-13 | — | — | US | disclosed |
| US-10980845-B2 | Probiotic and prebiotic compositions, and methods of use thereof for modulation of the microbiome | EVELO BIOSCIENCES, INC. (US) | 2021-04-20 | — | — | US | disclosed |
| US-10869903-B2 | Probiotic and prebiotic compositions, and methods of use thereof for treatment and prevention of graft versus host disease | EVELO BIOSCIENCES, INC. (US) | 2020-12-22 | — | — | US | disclosed |
| EP-3747450-A1 | PHARMACEUTICAL COMPOSITION CONSISTING OF BLAUTIA, FOR ORAL ADMINISTRATION | Evelo Biosciences, Inc. (US) | 2020-12-09 | — | — | EP | disclosed |
| EP-3223834-B1 | PROBIOTIC AND PREBIOTIC COMPOSITIONS COMPRISING BLAUTIA SPECIES FOR REDUCING INFLAMMATION | EVELO BIOSCIENCES INC (US) | 2020-05-06 | — | — | EP | disclosed |
| EP-2543726-B1 | Reduced genome E. coli | SCARAB GENOMICS LLC (US) | 2018-10-03 | — | — | EP | disclosed |
| US-20180169153-A1 | PROBIOTIC AND PREBIOTIC COMPOSITIONS, AND METHODS OF USE THEREOF FOR TREATMENT AND PREVENTION OF GRAFT VERSES HOST DISEASE | PHARMABIOME AG (CH) | 2018-06-21 | — | — | US | disclosed |
| US-20180071344-A1 | PROBIOTIC AND PREBIOTIC COMPOSITIONS, AND METHODS OF USE THEREOF FOR TREATMENT AND PREVENTION OF GRAFT VERSUS HOST DISEASE | PHARMABIOME AG (CH) | 2018-03-15 | — | — | US | disclosed |
| EP-3223834-A2 | PROBIOTIC AND PREBIOTIC COMPOSITIONS, AND METHODS OF USE THEREOF FOR MODULATION OF THE MICROBIOME | Evelo Biosciences, Inc. (US) | 2017-10-04 | — | — | EP | disclosed |
| US-20160199424-A1 | PROBIOTIC AND PREBIOTIC COMPOSITIONS, AND METHODS OF USE THEREOF FOR MODULATION OF THE MICROBIOME | PHARMABIOME AG (CH) | 2016-07-14 | — | — | US | disclosed |
| US-20160193258-A1 | PROBIOTIC AND PREBIOTIC COMPOSITIONS, AND METHODS OF USE THEREOF FOR TREATMENT AND PREVENTION OF GRAFT VERSUS HOST DISEASE | PHARMABIOME AG (CH) | 2016-07-07 | — | — | US | disclosed |
| WO-2016086205-A2 | PROBIOTIC AND PREBIOTIC COMPOSITIONS, AND METHODS OF USE THEREOF FOR MODULATION OF THE MICROBIOME | Epiva Biosciences, Inc. (US) | 2016-06-02 | — | — | WO | disclosed |
| US-20160143961-A1 | PROBIOTIC AND PREBIOTIC COMPOSITIONS, AND METHODS OF USE THEREOF FOR TREATMENT AND PREVENTION OF GRAFT VERSUS HOST DISEASE | PHARMABIOME AG (CH) | 2016-05-26 | — | — | US | disclosed |
| US-20150344838-A1 | REDUCED GENOME E. COLI | SCARAB GENOMICS, LLC (US) | 2015-12-03 | — | — | US | disclosed |
| US-9085765-B2 | Reduced genome E. coli | SCARAB GENOMICS LLC (US) | 2015-07-21 | — | — | US | disclosed |
| US-20130011874-A1 | REDUCED GENOME E. COLI | SCARAB GENOMICS, LLC (US) | 2013-01-10 | — | — | US | disclosed |
| EP-2543726-A1 | Reduced genome E. coli | Scarab Genomics, LLC (US) | 2013-01-09 | — | — | EP | disclosed |
| US-8178339-B2 | Reduced genome E. coli | SCARAB GENOMICS LLC (US) | 2012-05-15 | — | — | US | disclosed |
| US-20090075333-A1 | Reduced Genome E. Coli | SCARAB GENOMICS, LLC | 2009-03-19 | — | — | US | disclosed |