Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.72 |
| ▸ | MAPT | P10636 | 3/20 | 0.72 |
| ▸ | TSHR | P16473 | 3/20 | 0.62 |
| ▸ | HTT | P42858 | 2/20 | 0.62 |
| ▸ | GAA | P10253 | 2/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | TP53 | P04637 | 1/20 | 0.62 |
| ▸ | CNR1 | P21554 | 7/20 | 0.49 |
| ▸ | CNR2 | P34972 | 7/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | CASP1 | P29466 | 1/20 | 0.48 |
| ▸ | CASP7 | P55210 | 1/20 | 0.48 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11736088 | 0.86 | ALDH1A1 (0.67) | ALDH1A1MAPTTSHRHTTGAA | |
| Hydrochloric Acid SCHEMBL11739109 | 0.85 | ALDH1A1 (0.66) | ALDH1A1MAPTTSHRHTTGAA | |
| SCHEMBL11603069 | 0.84 | ALDH1A1 (0.61) | ALDH1A1MAPTTSHRHTTGAA | |
| SCHEMBL11760641 | 0.83 | ALDH1A1 (0.63) | ALDH1A1MAPTTSHRHTTGAA | |
| SCHEMBL280013 | 0.81 | ALDH1A1 (0.58) | ALDH1A1MAPTTSHRHTTGAA | |
| SCHEMBL11738042 | 0.81 | ALDH1A1 (0.61) | ALDH1A1MAPTTSHRHTTGAA | |
| Hydrochloric Acid SCHEMBL11739551 | 0.80 | ALDH1A1 (0.74) | ALDH1A1MAPTTSHRHTTGAA | |
| SCHEMBL11738683 | 0.80 | ALDH1A1 (0.60) | ALDH1A1MAPTTSHRHTTGAA | |
| SCHEMBL11739818 | 0.80 | ALDH1A1 (0.60) | ALDH1A1MAPTTSHRHTTGAA | |
| SCHEMBL11762213 | 0.80 | ALDH1A1 (0.60) | ALDH1A1MAPTTSHRHTTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8133887-B2 | Oxaphenanthrene derivatives | MERCK PATENT GMBH (DE) | 2012-03-13 | — | — | US | disclosed |
| US-8133887-B2 | Oxaphenanthrene derivatives | MERCK PATENT GMBH (DE) | 2012-03-13 | — | — | US | disclosed |
| EP-1963299-B1 | OXAPHENANTHRENE DERIVATIVES | MERCK PATENT GMBH (DE) | 2012-01-18 | — | — | EP | disclosed |
| US-20080312224-A1 | Oxaphenanthrene Derivatives | MERCK PATENT GMBH (DE) | 2008-12-18 | — | — | US | disclosed |
| US-20080312224-A1 | Oxaphenanthrene Derivatives | MERCK PATENT GMBH (DE) | 2008-12-18 | — | — | US | disclosed |
| EP-1963299-A1 | OXAPHENANTHRENE DERIVATIVES | Merck Patent GmbH (DE) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007079830-A1 | OXAPHENANTHRENE DERIVATIVES | MERCK PATENT GMBH (DE) | 2007-07-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080312224-A1 | Oxaphenanthrene Derivatives | CYP3A43, CYP1A1, CYP1A2 | ALDH1A1 347/4885MAPT 2738/4885TSHR 1983/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.