Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.64 |
| ▸ | TTR | P02766 | 1/20 | 0.64 |
| ▸ | PPOX | P50336 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.64 |
| ▸ | EIF4E | P06730 | 10/20 | 0.56 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.50 |
| ▸ | AKR1C4 | P17516 | 2/20 | 0.50 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.50 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.50 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | FABP4 | P15090 | 1/20 | 0.45 |
| ▸ | DTYMK | P23919 | 1/20 | 0.44 |
| ▸ | FLT1 | P17948 | 1/20 | 0.42 |
| ▸ | FLT4 | P35916 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Water SCHEMBL11042053 | 0.89 | TDP1 (0.51) | TDP1MEN1TTRPPOXKMT2A | |
| SCHEMBL28323202 | 0.89 | TDP1 (0.51) | TDP1MEN1TTRPPOXKMT2A | |
| SCHEMBL9444098 | 0.87 | TDP1 (0.49) | TDP1MEN1TTRPPOXKMT2A | |
| SCHEMBL9354317 | 0.83 | EIF4E (0.54) | TDP1EIF4EMAPTFABP4DTYMK | |
| SCHEMBL9354304 | 0.83 | EIF4E (0.54) | TDP1EIF4EMAPTFABP4DTYMK | |
| SCHEMBL16031334 | 0.83 | TTR (0.64) | TDP1MEN1TTRPPOXKMT2A | |
| Ether SCHEMBL11042007 | 0.82 | MEN1 (0.48) | TDP1MEN1TTRPPOXKMT2A | |
| SCHEMBL9783673 | 0.79 | KMT2A (0.43) | TDP1MEN1TTRPPOXKMT2A | |
| SCHEMBL9442020 | 0.79 | MEN1 (0.42) | TDP1MEN1TTRPPOXKMT2A | |
| SCHEMBL11061094 | 0.78 | CHEK1 (0.48) | TDP1MEN1TTRPPOXKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100432229-C | Manipulation of protoporphyrinogen oxidase enzyme activity in eukaryotes | CIBA GEIGY AG (CH) | 2008-11-12 | — | — | CN | disclosed |
| CN-1263856-C | Operation of enzymatic vitality of protoporphyrin primary oxidase in eukaryote | NOVARTIS AG (CH) | 2006-07-12 | — | — | CN | disclosed |
| CN-1193096-C | Operation for onzyme activity of protoporphyrin prooxidase in eukaryotic organism | SINGENTA PARTICIPATION AG (CH) | 2005-03-16 | — | — | CN | disclosed |
| CN-1382377-A | Operation for onzyme activity of protoporphyrin prooxidase in eukaryotic organism | SINGENTA PARTICIPATION AG (CH) | 2002-12-04 | — | — | CN | disclosed |
| CN-1309184-A | Operation of enzymatic vitality of protoporphyrin primary oxidase in eukaryote | NOVARTIS AG (CH) | 2001-08-22 | — | — | CN | disclosed |
| CN-1150820-A | Manipulation of protoporphyrinogen oxidase enzyme activity in eukaryotes | CIBA GEIGY AG (CH) | 1997-05-28 | — | — | CN | disclosed |