Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 14/20 | 0.73 |
| ▸ | RAF1 | P04049 | 2/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.73 |
| ▸ | MAPT | P10636 | 2/20 | 0.73 |
| ▸ | HPGD | P15428 | 2/20 | 0.73 |
| ▸ | TP53 | P04637 | 1/20 | 0.73 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.73 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.73 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.73 |
| ▸ | BRAF | P15056 | 1/20 | 0.73 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.73 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.73 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.73 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.73 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.73 |
| ▸ | SMO | Q99835 | 2/20 | 0.56 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27515239 | 0.93 | MAPK14 (0.62) | MAPK14RAF1KDM4EALDH1A1MAPT | |
| SCHEMBL27498043 | 0.91 | MAPK14 (0.60) | MAPK14RAF1KDM4EALDH1A1MAPT | |
| SCHEMBL27497052 | 0.88 | MAPK14 (0.56) | MAPK14RAF1KDM4EALDH1A1MAPT | |
| SCHEMBL27497712 | 0.87 | MAPK14 (0.55) | MAPK14RAF1KDM4EALDH1A1MAPT | |
| SCHEMBL27527556 | 0.86 | MAPK14 (0.75) | MAPK14RAF1KDM4EALDH1A1MAPT | |
| SCHEMBL27498040 | 0.85 | MAPK14 (0.78) | MAPK14RAF1KDM4EALDH1A1MAPT | |
| SCHEMBL27527548 | 0.85 | DEGS1 (0.54) | MAPK14RAF1KDM4EALDH1A1MAPT | |
| SCHEMBL29354376 | 0.84 | MAPK14 (1.00) | MAPK14RAF1KDM4EALDH1A1MAPT | |
| SCHEMBL29388528 | 0.84 | MAPK14 (1.00) | MAPK14RAF1KDM4EALDH1A1MAPT | |
| SCHEMBL1424183 | 0.84 | MAPK14 (1.00) | MAPK14RAF1KDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105579044-A | Use of dianhydrogalactitol and analogs and derivatives thereof for treating recurrent malignant glioma or progressive secondary brain tumor | DEL MAR PHARMACEUTICALS | 2016-05-11 | — | — | CN | disclosed |
| CN-104940126-A | Controlled-release otic structure modulating and innate immune system modulating compositions and methods for the treatment of otic disorders | OTONOMY INC | 2015-09-30 | — | — | CN | disclosed |
| CN-102105133-B | Controlled release otic structure modulating and innate immune system modulating compositions and methods of treating otic disorders | OTONOMY INC | 2015-06-17 | — | — | CN | disclosed |
| CN-104491864-A | Controlled Release Antimicrobial Compositions And Methods For The Treatment Of Otic Disorders | OTONOMY INC | 2015-04-08 | — | — | CN | disclosed |
| CN-102014957-B | Otic formulations for the treatment of otic diseases and conditions | OTONOMY INC | 2014-12-10 | — | — | CN | disclosed |
| CN-103814032-A | 4-oxo-3,5,7,8-tetrahydro-4h-pyrano{4,3-d} pyrminidinyl compounds for use as tankyrase inhibitors | NOVARTIS AG | 2014-05-21 | — | — | CN | disclosed |
| CN-103797006-A | 4-piperidinyl compounds useful as tankyrase inhibitors | NOVARTIS AG | 2014-05-14 | — | — | CN | disclosed |
| CN-103781776-A | Novel 2-piperidin-1-yl-acetamide compounds for use as tankyrase inhibitors | NOVARTIS AG | 2014-05-07 | — | — | CN | disclosed |
| CN-1185211-C | Benzamide derivatives for the treatment of diseases caused by cytokines | ASTRA ZENECA LTD (SE) | 2005-01-19 | — | — | CN | disclosed |
| CN-1271279-A | Amide derivatives for the treatment of diseases mediated by cytokines | ZENECA LTD (GB) | 2000-10-25 | — | — | CN | disclosed |