Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.46 |
| ▸ | KIT | P10721 | 2/20 | 0.46 |
| ▸ | FLT1 | P17948 | 2/20 | 0.46 |
| ▸ | KDR | P35968 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | NAMPT | P43490 | 5/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | NT5E | P21589 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27483911 | 0.83 | PDGFRB (0.47) | MAPTALDH1A1PDGFRBKITFLT1 | |
| SCHEMBL3152355 | 0.81 | FLT1 (0.64) | PDGFRBKITFLT1KDRPOLB | |
| SCHEMBL13955641 | 0.76 | PDGFRB (0.45) | GAAMAPTALDH1A1TDP1PDGFRB | |
| SCHEMBL13955450 | 0.74 | FLT1 (0.48) | MAPTPDGFRBKITFLT1KDR | |
| SCHEMBL13955448 | 0.72 | FLT1 (0.47) | GAAMAPTALDH1A1PDGFRBKIT | |
| SCHEMBL27511538 | 0.71 | FLT1 (0.60) | GAAMAPTALDH1A1TDP1PDGFRB | |
| SCHEMBL2203269 | 0.71 | FLT1 (0.46) | MAPTPDGFRBKITFLT1KDR | |
| SCHEMBL13955411 | 0.71 | KDR (0.48) | MAPTPDGFRBKITFLT1KDR | |
| SCHEMBL13955484 | 0.70 | KDR (0.50) | PDGFRBKITFLT1KDRMEN1 | |
| SCHEMBL13955593 | 0.70 | FLT1 (0.43) | MAPTPDGFRBKITFLT1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1319100-A | Isoquinoline derivatives having angiogenesis inhibitory activity | NOVARTIS AG (CH) | 2001-10-24 | — | — | CN | claimed |
| CN-105579044-A | Use of dianhydrogalactitol and analogs and derivatives thereof for treating recurrent malignant glioma or progressive secondary brain tumor | DEL MAR PHARMACEUTICALS | 2016-05-11 | — | — | CN | disclosed |
| CN-1152031-C | Isoquinoline derivatives having angiogenesis inhibitory activity | ��˹��ŵ�� | 2004-06-02 | — | — | CN | disclosed |