Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT1 | P17948 | 13/20 | 0.60 |
| ▸ | KDR | P35968 | 13/20 | 0.60 |
| ▸ | PDGFRB | P09619 | 10/20 | 0.54 |
| ▸ | KIT | P10721 | 9/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | CSF1R | P07333 | 2/20 | 0.42 |
| ▸ | FLT4 | P35916 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | NT5E | P21589 | 1/20 | 0.41 |
| ▸ | CIT | O14578 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | HLA-A | P04439 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4810051 | 0.81 | FLT1 (0.79) | FLT1KDRPDGFRBKITCSF1R | |
| SCHEMBL4821828 | 0.77 | FLT1 (0.81) | FLT1KDRPDGFRBKITCSF1R | |
| SCHEMBL27625198 | 0.74 | KDR (0.57) | FLT1KDRPDGFRBKITCSF1R | |
| SCHEMBL27625380 | 0.73 | KDR (0.65) | FLT1KDRPDGFRBKITGAA | |
| SCHEMBL28021680 | 0.73 | FLT1 (0.54) | FLT1KDRPDGFRBKITCSF1R | |
| SCHEMBL28752805 | 0.72 | FLT1 (0.64) | FLT1KDRPDGFRBKITALDH1A1 | |
| SCHEMBL14293515 | 0.72 | FLT1 (0.57) | FLT1KDRPDGFRBKITMAPT | |
| SCHEMBL4814239 | 0.72 | FLT1 (0.64) | FLT1KDRPDGFRBKITCSF1R | |
| SCHEMBL27486001 | 0.71 | GAA (0.52) | FLT1KDRPDGFRBKITGAA | |
| SCHEMBL28073018 | 0.70 | MAPT (0.64) | FLT1KDRPDGFRBKITMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1221262-C | Phthalazine derivatives for the treatment of inflammatory diseases | NOVARTIS AG (CH) | 2005-10-05 | — | — | CN | disclosed |
| CN-1660840-A | Phthalazine derivatives for treating inflammatory diseases | NOVARTIS AG (CH) | 2005-08-31 | — | — | CN | disclosed |
| CN-1367695-A | Phthalazine derivatives for the treatment of inflammatory diseases | NOVARTIS AG (CH) | 2002-09-04 | — | — | CN | disclosed |