Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 9/20 | 0.70 |
| ▸ | MAPK12 | P53778 | 9/20 | 0.70 |
| ▸ | MAPK11 | Q15759 | 9/20 | 0.70 |
| ▸ | MAPK14 | Q16539 | 9/20 | 0.70 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27529702 | 0.86 | MAPK14 (0.78) | MAPK13MAPK12MAPK11MAPK14GRM4 | |
| SCHEMBL1907064 | 0.83 | MAPK13 (0.65) | MAPK13MAPK12MAPK11MAPK14KMT2A | |
| SCHEMBL6654823 | 0.83 | MAPK14 (1.00) | MAPK13MAPK12MAPK11MAPK14GRM4 | |
| SCHEMBL27555322 | 0.82 | MAPK13 (0.62) | MAPK13MAPK12MAPK11MAPK14KMT2A | |
| SCHEMBL1907099 | 0.82 | MAPK14 (1.00) | MAPK13MAPK12MAPK11MAPK14KMT2A | |
| SCHEMBL7079677 | 0.80 | MAPK13 (0.60) | MAPK13MAPK12MAPK11MAPK14GRM4 | |
| SCHEMBL28901163 | 0.79 | MAPK13 (0.63) | MAPK13MAPK12MAPK11MAPK14KMT2A | |
| SCHEMBL6657882 | 0.79 | MAPK13 (0.73) | MAPK13MAPK12MAPK11MAPK14GRM4 | |
| SCHEMBL11716980 | 0.78 | APEX1 (0.61) | MAPK13MAPK12MAPK11MAPK14GRM4 | |
| SCHEMBL27655411 | 0.78 | MAPK13 (0.60) | MAPK13MAPK12MAPK11MAPK14KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1193003-C | Aminobenzophenones as inhibitors of IL-1 beta and TNF-alpha | LEO PHARM PROD LTD (DK) | 2005-03-16 | — | — | CN | claimed |
| CN-1413186-A | Aminobenzophenones as inhibitors of IL-1 beta and TNF-alpha | LEO PHARM PROD LTD (DK) | 2003-04-23 | — | — | CN | claimed |
| CN-1193003-C | Aminobenzophenones as inhibitors of IL-1 beta and TNF-alpha | LEO PHARM PROD LTD (DK) | 2005-03-16 | — | — | CN | disclosed |
| CN-1413186-A | Aminobenzophenones as inhibitors of IL-1 beta and TNF-alpha | LEO PHARM PROD LTD (DK) | 2003-04-23 | — | — | CN | disclosed |