Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.50 |
| ▸ | EGLN1 | Q9GZT9 | 3/20 | 0.50 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.50 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.50 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.41 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | SLC13A3 | Q8WWT9 | 1/20 | 0.39 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.39 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Adipic Acid SCHEMBL27869015 | 0.90 | LMNA (0.55) | LMNASLC22A6ALDH1A1TSHRNFKB1 | |
| SCHEMBL29273133 | 0.82 | EGLN2 (0.34) | NR4A2BCHEL3MBTL1RAB9A | |
| Bicarbonate SCHEMBL9005252 | 0.82 | CA1 (0.36) | LMNAL3MBTL1CYP1A2 | |
| Chloroacetic Acid SCHEMBL29007385 | 0.81 | TSHR (0.53) | MAPK1ALDH1A1TSHRRAB9AHIF1A | |
| Propionic Acid SCHEMBL28112393 | 0.81 | FFAR3 (0.53) | LMNAL3MBTL1ALDH1A1CYP1A2SMN1; SMN2 | |
| Bicarbonate SCHEMBL29455645 | 0.79 | CA1 (0.33) | — | |
| Propionic Acid SCHEMBL28056926 | 0.79 | FFAR3 (0.50) | L3MBTL1ALDH1A1CYP1A2SMN1; SMN2FFAR3 | |
| Succinic Acid SCHEMBL4739951 | 0.78 | LMNA (0.82) | LMNAEGLN1ALKBH5SUCNR1NR4A2 | |
| Hydrogen Peroxide SCHEMBL27500303 | 0.78 | — | — | |
| Glycolic Acid SCHEMBL6271103 | 0.77 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1200681-C | Packaged hair colouring composition | UNIV OF NORTH CAROLINA (US) | 2005-05-11 | — | — | CN | disclosed |
| CN-1303265-A | Packaged hair colouring composition | PROCTER & GAMBLE (US) | 2001-07-11 | — | — | CN | disclosed |