Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK2 | Q9HBH9 | 4/20 | 0.64 |
| ▸ | CDK1 | P06493 | 3/20 | 0.64 |
| ▸ | CDK2 | P24941 | 3/20 | 0.64 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.64 |
| ▸ | FYN | P06241 | 5/20 | 0.48 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2750714 | 0.90 | CHEK2 (0.55) | MKNK2CDK1CDK2MKNK1CHEK2 | |
| SCHEMBL2750376 | 0.89 | ATR (0.54) | MKNK2CDK1CDK2MKNK1FYN | |
| SCHEMBL2747422 | 0.89 | MAP4K4 (0.58) | MKNK2CDK1CDK2MKNK1FYN | |
| SCHEMBL2750253 | 0.88 | FYN (0.54) | MKNK2CDK1CDK2MKNK1FYN | |
| SCHEMBL2748849 | 0.87 | CDK8 (0.50) | MKNK2CDK1CDK2MKNK1FYN | |
| SCHEMBL2747417 | 0.86 | CDK8 (0.49) | MKNK2CDK1CDK2MKNK1FYN | |
| SCHEMBL2748635 | 0.85 | CDK1 (0.48) | MKNK2CDK1CDK2MKNK1FYN | |
| SCHEMBL2749569 | 0.85 | MKNK1 (0.48) | MKNK2CDK1CDK2MKNK1FYN | |
| SCHEMBL2748906 | 0.84 | PRKD3 (0.62) | MKNK2CDK1CDK2MKNK1FYN | |
| SCHEMBL2749700 | 0.82 | ATR (0.52) | FYNMAP4K4ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8178668-B2 | 2-aminopyridine kinase inhibitors | OSI Pharmaceuticals, LLC (US) | 2012-05-15 | — | — | US | disclosed |
| US-20090197862-A1 | 2-AMINOPYRIDINE KINASE INHIBITORS | OSI PHARMACEUTICALS, INC. | 2009-08-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090197862-A1 | 2-AMINOPYRIDINE KINASE INHIBITORS | ERBB2, ABL2, TIE1 | MKNK2 142/4885CDK1 298/4885CDK2 191/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.