Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 3/20 | 0.33 |
| ▸ | DRD2 | P14416 | 3/20 | 0.32 |
| ▸ | DRD3 | P35462 | 3/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | DRD1 | P21728 | 1/20 | 0.31 |
| ▸ | DRD4 | P21917 | 1/20 | 0.31 |
| ▸ | DRD5 | P21918 | 1/20 | 0.31 |
| ▸ | CCR4 | P51679 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25854093 | 0.83 | HCRTR2 (0.35) | DRD2DRD3CCR4 | |
| SCHEMBL27472793 | 0.81 | CARM1 (0.33) | DRD2KDM4E | |
| SCHEMBL665189 | 0.77 | DRD2 (0.34) | BCHEDRD2DRD3OPRM1DRD1 | |
| SCHEMBL4373653 | 0.77 | CYP2D6 (0.40) | BCHEDRD2DRD3OPRM1 | |
| SCHEMBL7694113 | 0.77 | DRD2 (0.31) | BCHEDRD2DRD3DRD1DRD4 | |
| SCHEMBL666336 | 0.76 | DRD2 (0.35) | BCHEDRD2DRD3OPRM1DRD1 | |
| SCHEMBL27511929 | 0.76 | CYP3A4 (0.37) | BCHEDRD2DRD3KDM4E | |
| SCHEMBL665211 | 0.76 | DRD2 (0.33) | BCHEDRD2DRD3OPRM1DRD1 | |
| SCHEMBL27491696 | 0.76 | KDM2B (0.39) | KDM4E | |
| SCHEMBL4373649 | 0.75 | CARM1 (0.35) | BCHEDRD2DRD3OPRM1DRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1161352-C | Quinazoline derivatives | — | 2004-08-11 | — | — | CN | claimed |
| CN-1322202-A | Quinazoline derivatives | ASTRA ZENECA N V (SE) | 2001-11-14 | — | — | CN | claimed |
| CN-100360505-C | Quinazoline derivatives as angiogenesis inhibitors | ASTRAZENECA AB (SE) | 2008-01-09 | — | — | CN | disclosed |
| CN-1597667-A | Quinazoline derivatives as angiogenesis inhibitors | ASTRAZENECA AB (SE) | 2005-03-23 | — | — | CN | disclosed |
| CN-1161352-C | Quinazoline derivatives | — | 2004-08-11 | — | — | CN | disclosed |
| CN-1322202-A | Quinazoline derivatives | ASTRA ZENECA N V (SE) | 2001-11-14 | — | — | CN | disclosed |