Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.75 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.52 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.52 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6304036 | 0.86 | SIGMAR1 (0.58) | SIGMAR1POLBLMNAOPRK1GRM7 | |
| SCHEMBL6304033 | 0.86 | SIGMAR1 (0.58) | SIGMAR1POLBLMNAOPRK1GRM7 | |
| SCHEMBL9516955 | 0.86 | SIGMAR1 (0.67) | SIGMAR1OPRM1OPRK1CHRNA7 | |
| SCHEMBL10340117 | 0.86 | SIGMAR1 (1.00) | SIGMAR1OPRM1OPRK1SMN1; SMN2 | |
| SCHEMBL7344793 | 0.86 | SIGMAR1 (1.00) | SIGMAR1OPRM1OPRK1SMN1; SMN2 | |
| SCHEMBL10340111 | 0.83 | SIGMAR1 (0.95) | SIGMAR1OPRM1OPRK1 | |
| SCHEMBL10340110 | 0.83 | SIGMAR1 (0.95) | SIGMAR1OPRM1OPRK1 | |
| SCHEMBL6307072 | 0.81 | SIGMAR1 (0.53) | SIGMAR1POLBLMNAGRM7SMN1; SMN2 | |
| SCHEMBL6303612 | 0.81 | SIGMAR1 (0.53) | SIGMAR1POLBLMNA | |
| SCHEMBL6303615 | 0.81 | SIGMAR1 (0.53) | SIGMAR1POLBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101432011-A | Method for regulating neurotransmitter systems by inducing counteradaptation | ALEXANDER MICHALOW (US) | 2009-05-13 | — | — | CN | disclosed |
| CN-101065014-A | Method for regulating neurotransmitter systems by inducing counteradaptation | ALEXANDER MICHALOW (US) | 2007-10-31 | — | — | CN | disclosed |
| CN-1204264-A | Production of analgesic synergy by co-administration of sub-analgesic doses of a mu opioid agonist and kappa-2 opioid agonist | UNIV QUEENSLAND (AU) | 1999-01-06 | — | — | CN | disclosed |