Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | MERTK | Q12866 | 1/20 | 0.32 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.31 |
| ▸ | AHR | P35869 | 1/20 | 0.31 |
| ▸ | FOS | P01100 | 1/20 | 0.30 |
| ▸ | JUN | P05412 | 1/20 | 0.30 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.30 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.30 |
| ▸ | RELA | Q04206 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5416240 | 0.78 | LMNA (0.43) | LMNAKDM4EHTTMEN1KMT2A | |
| SCHEMBL15785397 | 0.78 | LMNA (0.40) | LMNAKDM4EHTTMEN1KMT2A | |
| SCHEMBL5402443 | 0.77 | LRRK2 (0.50) | LMNAKDM4EHTTMEN1KMT2A | |
| SCHEMBL5407989 | 0.77 | LMNA (0.42) | LMNAKDM4EHTTMEN1KMT2A | |
| SCHEMBL12876461 | 0.77 | KDM4E (0.42) | LMNAKDM4EHTTMEN1KMT2A | |
| SCHEMBL28300418 | 0.77 | KDM4E (0.42) | LMNAKDM4EHTTMEN1KMT2A | |
| SCHEMBL16134092 | 0.74 | LMNA (0.40) | LMNAKDM4EHTTMEN1KMT2A | |
| SCHEMBL14609722 | 0.74 | LMNA (0.40) | LMNAKDM4EHTTMEN1KMT2A | |
| SCHEMBL1521592 | 0.74 | LMNA (0.40) | LMNAKDM4EHTTMEN1KMT2A | |
| SCHEMBL5411406 | 0.74 | KDM4E (0.56) | LMNAKDM4EHTTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100386328-C | Bicyclic pyridine and pyrimidine P38 kinase inhibitors | HOFFMANN LA ROCHE (CH) | 2008-05-07 | — | — | CN | disclosed |
| CN-100358892-C | 7-oxopyridopyrimidines | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | CN | disclosed |
| CN-1303072-C | 7-oxo pyridopyrimidines | HOFFMANN LA ROCHE (CH) | 2007-03-07 | — | — | CN | disclosed |
| CN-1275964-C | 7-oxo pyridopyrimidines as inhibitors of a cellular proliferation | HOFFMANN LA ROCHE (CH) | 2006-09-20 | — | — | CN | disclosed |
| CN-1721412-A | 7-oxo pyridopyrimidines | HOFFMANN LA ROCHE (CH) | 2006-01-18 | — | — | CN | disclosed |
| CN-1639168-A | Bicyclic pyridine and pyrimidine P38 kinase inhibitors | HOFFMANN LA ROCHE (CH) | 2005-07-13 | — | — | CN | disclosed |
| CN-1171889-C | Heteroalkylamino-substituted bicyclic nitrogen heterocycles as inhibitors of P38 protein kinase | - | 2004-10-20 | — | — | CN | disclosed |
| CN-1451005-A | 7-oxopyridopyrimidines as inhibitors of cell proliferation | HOFFMANN LA ROCHE (CH) | 2003-10-22 | — | — | CN | disclosed |
| CN-1451004-A | 7-oxopyridopyrimidines | HOFFMANN LA ROCHE (CH) | 2003-10-22 | — | — | CN | disclosed |
| CN-1382144-A | Heteroalkylamino-substituted bicyclic nitrogen heterocycles as inhibitors of P38 protein kinase | HOFFMANN LA ROCHE (CH) | 2002-11-27 | — | — | CN | disclosed |