⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL293363 | 0.76 | — | — | |
| SCHEMBL17131097 | 0.76 | — | — | |
| SCHEMBL13637530 | 0.76 | — | — | |
| SCHEMBL159078 | 0.76 | — | — | |
| SCHEMBL965094 | 0.76 | — | — | |
| SCHEMBL27975158 | 0.76 | — | — | |
| SCHEMBL18531888 | 0.76 | — | — | |
| Hydrochloric Acid SCHEMBL31284299 | 0.74 | — | — | |
| Hydrochloric Acid SCHEMBL27397572 | 0.74 | — | — | |
| SCHEMBL4557079 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103339117-B | 1,4 oxazines as bace1 and/or bace2 inhibitors | HOFFMANN LA ROCHE | 2015-05-27 | — | — | CN | disclosed |
| CN-103328454-A | 1,4 oxazines as BACE1 and/or BACE2 inhibitors | HOFFMANN LA ROCHE | 2013-09-25 | — | — | CN | disclosed |
| CN-1649883-B | Bicyclic 6-alkylidene-epimycotenes as lactamase inhibitors | WYETH CORP | 2010-05-26 | — | — | CN | disclosed |
| CN-101570545-A | Bicyclic 6-alkylidene-penems as beta-lactamase inhibitors | WYETH CORP (US) | 2009-11-04 | — | — | CN | disclosed |
| CN-100516069-C | Process for preparing 6-alkylidene penem derivatives | WYETH CORP (US) | 2009-07-22 | — | — | CN | disclosed |
| CN-101232881-A | Bicyclic 6-alkylidene-penem beta-lactamase inhibitors and beta-lactam antibiotic combination: a broad spectrum antibiotic | WYETH CORP (US) | 2008-07-30 | — | — | CN | disclosed |
| CN-101217955-A | Bicyclic 6-alkylidene-penems as class D beta-lactamases inhibitors | WYETH CORP (US) | 2008-07-09 | — | — | CN | disclosed |
| CN-1216874-C | (Hetero) aryl-substituted heterocyclic enaminones, production therof and use thereof as herbicides, acaricides and insecticides | BAYER AG (DE) | 2005-08-31 | — | — | CN | disclosed |
| CN-1649881-A | Process for preparing 6-alkylidene penem derivatives | WYETH CORP (US) | 2005-08-03 | — | — | CN | disclosed |
| CN-1649883-A | Bicyclic 6-alkylidene-epimycotenes as lactamase inhibitors | WYETH CORP (US) | 2005-08-03 | — | — | CN | disclosed |
| CN-1407977-A | (Hetero) aryl-substituted heterocyclic enaminones, production therof and use thereof as herbicides, acaricides and insecticides | BAYER AG (DE) | 2003-04-02 | — | — | CN | disclosed |