Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | NCEH1 | Q6PIU2 | 8/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.42 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.42 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | PGR | P06401 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7942009 | 0.83 | TSHR (0.47) | HSD17B10NCEH1CYP1A2CYP2A6TSHR | |
| SCHEMBL453345 | 0.83 | KDM4E (0.58) | HSD17B10NCEH1CYP1A2CYP2A6TSHR | |
| SCHEMBL29356413 | 0.83 | KDM4E (0.58) | HSD17B10NCEH1CYP1A2CYP2A6TSHR | |
| SCHEMBL11867995 | 0.81 | TSHR (0.46) | HSD17B10NCEH1CYP1A2CYP2A6TSHR | |
| SCHEMBL6929061 | 0.81 | TSHR (0.46) | HSD17B10NCEH1CYP1A2CYP2A6TSHR | |
| SCHEMBL23271769 | 0.81 | HSD17B10 (0.49) | HSD17B10CYP1A2ALDH1A1PGRGAA | |
| SCHEMBL6938277 | 0.80 | NCEH1 (0.52) | HSD17B10NCEH1ALDH1A1PGRGAA | |
| SCHEMBL11042128 | 0.80 | TSHR (0.44) | HSD17B10NCEH1CYP1A2CYP2A6TSHR | |
| SCHEMBL11042135 | 0.80 | TSHR (0.44) | HSD17B10NCEH1CYP1A2CYP2A6TSHR | |
| SCHEMBL14937495 | 0.79 | KMT2A (0.50) | HSD17B10CYP1A2CYP2A6TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8350060-B2 | 2-amino-bicyclo[3.1.0] hexane-2, 6-dicarboxylic ester derivative | Taisho Pharamceutical Co., Ltd. (JP) | 2013-01-08 | — | — | US | disclosed |
| US-8258133-B2 | 2-amino-bicyclo[3.1.0]hexane-2, 6-dicarboxylic ester derivative | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2012-09-04 | — | — | US | disclosed |
| US-20120028982-A1 | 2-AMINO-BICYCLO[3.1.0]HEXANE-2, 6-DICARBOXYLIC ESTER DERIVATIVE | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2012-02-02 | — | — | US | disclosed |
| US-20120004232-A1 | 2-AMINO-BICYCLO(3.1.0) HEXANE-2, 6-DICARBOXYLIC ESTER DERIVATIVE | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2012-01-05 | — | — | US | disclosed |
| US-6045590-A | REPLACING 2-METHYL-1-NAPHTHOL WITH A MOLAR EQUIVALENT OF A 1-(ALKOXYCARBONYLOXY OR ALKYLCARBONYLOXY),2-METHYL-NAPHTHYLENE OR 2-METHYL,4-((HYDROXY)(ALKOXY)ALKOXY)-NAPHTH-1-OL; STORAGE STABLE HAIR DYES PRODUCE SAME COLOR | BRISTOL-MYERS SQUIBB CO. (US) | 2000-04-04 | — | — | US | disclosed |
| US-5672180-A | USED IN OXIDATIVE HAIR DYE SYSTEMS | CLAIROL INCORPORATED (US) | 1997-09-30 | — | — | US | disclosed |
| US-5529583-A | HAIR DYE | CLAIROL INCORPORATED (US) | 1996-06-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120028982-A1 | 2-AMINO-BICYCLO[3.1.0]HEXANE-2, 6-DICARBOXYLIC ESTER DERIVATIVE | GRIK4, GRIN2D, GRIN2C | HSD17B10 551/4885NCEH1 895/4885CYP1A2 993/4885 |
| US-20120004232-A1 | 2-AMINO-BICYCLO(3.1.0) HEXANE-2, 6-DICARBOXYLIC ESTER DERIVATIVE | GRIK4, GRIN2D, GRIN2C | HSD17B10 522/4885NCEH1 925/4885CYP1A2 1040/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.