SCHEMBL453345

SCHEMBL453345

CC(=O)Oc1c(C)ccc2ccccc12

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 3/20 0.58
HTT P42858 2/20 0.58
HSD17B10 Q99714 2/20 0.58
MAPT P10636 2/20 0.58
TP53 P04637 1/20 0.58
GAA P10253 1/20 0.58
ALDH1A1 P00352 3/20 0.49
HPGD P15428 2/20 0.49
TSHR P16473 2/20 0.47
CYP2A6 P11509 2/20 0.47
CYP1A2 P05177 1/20 0.47
GSK3B P49841 2/20 0.47
ADK P55263 2/20 0.47
NCEH1 Q6PIU2 3/20 0.44
SLC22A6 Q4U2R8 1/20 0.44
TAS1R3 Q7RTX0 1/20 0.40
TAS1R1 Q7RTX1 1/20 0.40
TAS1R2 Q8TE23 1/20 0.40
NPC1 O15118 1/20 0.40
PKM P14618 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29356413 1.00 KDM4E (0.58) KDM4EHTTHSD17B10MAPTTP53
SCHEMBL7113059 0.88 HTT (0.55) KDM4EHTTHSD17B10MAPTTP53
SCHEMBL7942009 0.86 TSHR (0.47) KDM4EHTTHSD17B10MAPTTP53
SCHEMBL3163084 0.85 HTT (0.55) KDM4EHTTHSD17B10MAPTTP53
SCHEMBL11867995 0.84 TSHR (0.46) KDM4EHTTHSD17B10MAPTTP53
SCHEMBL6929061 0.84 TSHR (0.46) KDM4EHTTHSD17B10MAPTTP53
SCHEMBL819579 0.83 MAPT (0.42) KDM4EHTTHSD17B10MAPTTP53
SCHEMBL11042135 0.83 TSHR (0.44) KDM4EHTTHSD17B10MAPTTP53
SCHEMBL2749709 0.83 HSD17B10 (0.46) HTTHSD17B10GAAALDH1A1HPGD
SCHEMBL11042128 0.83 TSHR (0.44) KDM4EHTTHSD17B10MAPTTP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1852 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260144724-A1 Mixture of at least five surfactants (I1) to (I5) WELLA GERMANY GMBH (DE) 2026-05-28 US claimed
US-12636241-B1 Method and composition for oxidative hair coloring WELLA OPERATIONS US LLC (US) 2026-05-26 US claimed
EP-4739272-A1 OXIDATIVE HAIR COLOURING COMPOSITION Wella Germany GmbH (DE) 2026-05-13 EP claimed
EP-4731170-A1 OXIDATIVE HAIR COLOURING COMPOSITION COMPRISING A CHELANT MIXTURE Wella Germany GmbH (DE) 2026-04-29 EP claimed
US-12564545-B2 Hair coloring compositions comprising 2-amino-1-propanol as alkalising agents WELLA GERMANY GMBH (DE) 2026-03-03 US claimed
US-12383482-B2 Hair coloring compositions WELLA GERMANY GMBH (DE) 2025-08-12 US claimed
EP-4552630-A1 RESORCINOL FREE PERMANENT HAIR COLOR COMPOSITION AND METHOD Wella Operations US, LLC (US) 2025-05-14 EP claimed
WO-2025031867-A1 OXIDATIVE HAIR COLOURING COMPOSITION COMPRISING A CHELANT MIXTURE WELLA GERMANY GMBH (DE) 2025-02-13 WO claimed
WO-2025008339-A1 OXIDATIVE HAIR COLOURING COMPOSITION WELLA GERMANY GMBH (DE) 2025-01-09 WO claimed
US-20240342067-A1 Hair Coloring Compositions Comprising 2-Amino-1-Propanol As Alkalising Agents WELLA GERMANY GMBH (DE) 2024-10-17 US claimed
US-6264703-B1 FOR DYEING HAIR CLAIROL INCORPORATED 2001-07-24 US claimed
EP-1116711-A2 2-aminoalkyl-1,4-diaminobenzene derivatives and dye composition containing these compounds Wella Aktiengesellschaft (DE) 2001-07-18 EP claimed
EP-1068860-A1 Dyeing composition containing 1-acetoxy naphthalene, two oxidation bases and a coupling agent L'OREAL (FR) 2001-01-17 EP claimed
US-6132475-A FOR OXIDATION DYEING OF KERATIN FIBERS; INCLUDES COUPLER AND DEVELOPER, IN WHICH THE DEVELOPER IS A SUBSTITUTED 2-(FURYL, THIENYL, PYRROLYL, OR SELENOPHENE) P-DIAMINOBENZENE DERIVATIVE OF GIVEN FORMULA; COLORFASTNESS, WASHFASTNESS WELLA AKTIENGESELLSCHAFT (DE) 2000-10-17 US claimed
EP-0825172-B1 Synthesis of 1-acetoxy-2-methylnaphthalene BRISTOL MYERS SQUIBB CO (US) 2000-04-26 EP claimed
US-6042620-A FOR DYEING KERATIN FIBERS SUCH AS HAIR WELLA AG (DE) 2000-03-28 US claimed
EP-0963982-A2 New diaminobenzene derivatives and these componends containing colouring agents Wella Aktiengesellschaft (DE) 1999-12-15 EP claimed
EP-0943614-A2 Dyeing agents comprising diaminobenzene derivatives and the diaminobenzene derivatives Wella Aktiengesellschaft (DE) 1999-09-22 EP claimed
EP-0825172-A1 Synthesis of 1-acetoxy-2-methylnaphthalene Bristol-Myers Squibb Company (US) 1998-02-25 EP claimed
US-5670698-A Synthesis of 1-acetoxy-2-methylnaphthalene BRISTOL-MYERS SQUIBB COMPANY (US) 1997-09-23 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12564545-B2 Hair coloring compositions comprising 2-amino-1-propanol as alkalising agents PHOSPHO1, ALDH7A1, AASDHPPT KDM4E 1524/4885HTT 1425/4885HSD17B10 1197/4885
US-12636241-B1 Method and composition for oxidative hair coloring POLB, DAO, ALPP KDM4E 2019/4885HTT 3296/4885HSD17B10 279/4885
US-20240342067-A1 Hair Coloring Compositions Comprising 2-Amino-1-Propanol As Alkalising Agents ALDH7A1, PTMA, AAAS KDM4E 1512/4885HTT 1086/4885HSD17B10 1781/4885
US-20260144724-A1 Mixture of at least five surfactants (I1) to (I5) DEGS1, SGMS1, FABP4 KDM4E 3739/4885HTT 1492/4885HSD17B10 604/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.