Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CRHR1 | P34998 | 11/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.34 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.34 |
| ▸ | CD38 | P28907 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27476315 | 0.84 | GAA (0.38) | GAAMAPTCRHR1MEN1KMT2A | |
| SCHEMBL27450019 | 0.84 | CRHR1 (0.54) | MAPTCRHR1MEN1KMT2ATP53 | |
| SCHEMBL27451382 | 0.79 | CRHR1 (0.55) | CRHR1NR4A2 | |
| SCHEMBL27489800 | 0.77 | CRHR1 (0.38) | CRHR1MEN1KMT2ANR4A2KDM4E | |
| SCHEMBL6093075 | 0.76 | CRHR1 (0.60) | GAAMAPTCRHR1MEN1KMT2A | |
| SCHEMBL27468681 | 0.74 | CRHR1 (0.69) | CRHR1 | |
| SCHEMBL27466339 | 0.73 | CRHR1 (0.35) | MAPTCRHR1MEN1KMT2ANR4A2 | |
| Hydrochloric Acid SCHEMBL27771297 | 0.73 | MEN1 (0.33) | MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL27771375 | 0.71 | MEN1 (0.33) | MAPTMEN1KMT2ATP53NUDT1 | |
| SCHEMBL7219924 | 0.70 | TP53 (0.54) | GAAMAPTMEN1KMT2ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1191236-C | Substituted 6,6-Hetero-dicycloderivative | PFIZER (US) | 2005-03-02 | — | — | CN | disclosed |
| CN-1138774-C | Substituted 6, 6-hetero-bicyclic derivatives | — | 2004-02-18 | — | — | CN | disclosed |
| CN-1367169-A | Substituted 6,6-Hetero-dicycloderivative | PFIZER (US) | 2002-09-04 | — | — | CN | disclosed |
| CN-1228091-A | Substituted 6, 6-hetero-bicyclic derivatives | PFIZER (US) | 1999-09-08 | — | — | CN | disclosed |