Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | CYP19A1 | P11511 | 6/20 | 0.53 |
| ▸ | CTSV | O60911 | 4/20 | 0.53 |
| ▸ | CTSL | P07711 | 4/20 | 0.53 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.52 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.46 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.46 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL371744 | 0.86 | MEN1 (0.65) | MEN1KMT2AMAPTCYP19A1CTSV | |
| SCHEMBL1319458 | 0.81 | CTSV (0.63) | MEN1KMT2AMAPTCYP19A1CTSV | |
| SCHEMBL1647948 | 0.79 | CYP19A1 (0.64) | MEN1KMT2AMAPTCYP19A1CTSV | |
| SCHEMBL26621356 | 0.78 | CYP19A1 (0.53) | MEN1KMT2AMAPTCYP19A1CTSV | |
| SCHEMBL30152254 | 0.78 | MEN1 (0.51) | MEN1KMT2AMAPTCYP19A1ALDH1A1 | |
| SCHEMBL3366592 | 0.78 | MEN1 (0.51) | MEN1KMT2AMAPTCYP19A1ALDH1A1 | |
| Nitrobenzene SCHEMBL28085437 | 0.77 | PTGER1 (0.50) | MEN1KMT2AMAPTCYP19A1CTSV | |
| SCHEMBL1162221 | 0.77 | PTGER1 (0.54) | MEN1KMT2AMAPTCYP19A1CTSV | |
| SCHEMBL5839822 | 0.77 | KMT2A (0.74) | MEN1KMT2ACYP19A1CTSVCTSL | |
| SCHEMBL8808139 | 0.76 | MEN1 (0.69) | MEN1KMT2AMAPTCYP19A1CTSV |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1167422-C | Quinazoline derivatives as angiogenesis inhibitors | — | 2004-09-22 | — | — | CN | disclosed |
| CN-1346271-A | Quinazoline derivatives as angiogenesis inhibitors | ASTRAZENECA UK LTD (SE) | 2002-04-24 | — | — | CN | disclosed |