Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 2/20 | 0.42 |
| ▸ | MAP2K1 | Q02750 | 10/20 | 0.41 |
| ▸ | MAP2K2 | P36507 | 5/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.40 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.40 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27469368 | 0.89 | MEN1 (0.51) | MEN1KMT2ATDP1PTGS2IDO1 | |
| SCHEMBL27471400 | 0.88 | MAP2K1 (0.53) | IDO1MAP2K1MAP2K2HDAC3HDAC4 | |
| SCHEMBL6035920 | 0.87 | MAP2K1 (0.55) | MEN1KMT2ATDP1PTGS2IDO1 | |
| SCHEMBL7715687 | 0.86 | MAP2K1 (0.56) | MEN1KMT2ATDP1PTGS2IDO1 | |
| SCHEMBL27455273 | 0.85 | MEN1 (0.49) | MEN1KMT2ATDP1PTGS2IDO1 | |
| SCHEMBL5388138 | 0.85 | MAP2K1 (0.60) | MEN1KMT2ATDP1MAP2K1MAP2K2 | |
| SCHEMBL27583296 | 0.85 | MAP2K1 (0.61) | MEN1KMT2ATDP1PTGS2MAP2K1 | |
| SCHEMBL27577420 | 0.83 | KMT2A (0.40) | MEN1KMT2APTGS2MAP2K1MAP2K2 | |
| SCHEMBL5403672 | 0.82 | MEN1 (0.66) | MEN1KMT2ATDP1IDO1MAP2K1 | |
| SCHEMBL27485120 | 0.82 | MEN1 (0.55) | MEN1KMT2ATDP1MAP2K1MAP2K2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1163475-C | 4-bromo or 4-iodo phenylamino benzhydroxamic acid derivatives and their use as MEK inhibitors | ��ʲ | 2004-08-25 | — | — | CN | claimed |
| CN-1383823-A | Methods of treating or inhibiting neutrophil chemotaxis by administering MEK inhibitors | WARNER LAMBERT CO (US) | 2002-12-11 | — | — | CN | claimed |
| CN-1373660-A | Method for treating chronic pain using MEK inhibitors | WARNER LAMBERT CO (US) | 2002-10-09 | — | — | CN | claimed |
| CN-1261877-A | 4-bromo or 4-iodo phenylamino benzhydroxamic acid derivatives and their use as MEK inhibitors | WARNER LAMBERT CO (US) | 2000-08-02 | — | — | CN | claimed |
| CN-1163475-C | 4-bromo or 4-iodo phenylamino benzhydroxamic acid derivatives and their use as MEK inhibitors | ��ʲ | 2004-08-25 | — | — | CN | disclosed |
| CN-1383823-A | Methods of treating or inhibiting neutrophil chemotaxis by administering MEK inhibitors | WARNER LAMBERT CO (US) | 2002-12-11 | — | — | CN | disclosed |
| CN-1373660-A | Method for treating chronic pain using MEK inhibitors | WARNER LAMBERT CO (US) | 2002-10-09 | — | — | CN | disclosed |
| CN-1261877-A | 4-bromo or 4-iodo phenylamino benzhydroxamic acid derivatives and their use as MEK inhibitors | WARNER LAMBERT CO (US) | 2000-08-02 | — | — | CN | disclosed |