Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 11/20 | 0.61 |
| ▸ | MAP2K2 | P36507 | 5/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | TYK2 | P29597 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.41 |
| ▸ | GPR52 | Q9Y2T5 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6438484 | 0.87 | MAP2K1 (0.47) | MAP2K1MAP2K2MEN1KMT2ATDP1 | |
| SCHEMBL6036443 | 0.87 | MAP2K1 (0.81) | MAP2K1MAP2K2MEN1KMT2ATDP1 | |
| SCHEMBL6951788 | 0.86 | MAP2K2 (0.46) | MAP2K1MAP2K2MEN1KMT2ATDP1 | |
| SCHEMBL27469368 | 0.86 | MEN1 (0.51) | MAP2K1MAP2K2MEN1KMT2ATDP1 | |
| SCHEMBL27508573 | 0.85 | MEN1 (0.47) | MAP2K1MAP2K2MEN1KMT2ATDP1 | |
| SCHEMBL27563907 | 0.85 | SMN1; SMN2 (0.56) | MAP2K1MAP2K2MEN1KMT2ATDP1 | |
| SCHEMBL6694982 | 0.82 | MAP2K1 (0.53) | MAP2K1MAP2K2JAK1TYK2PTGS2 | |
| SCHEMBL6035920 | 0.82 | MAP2K1 (0.55) | MAP2K1MAP2K2MEN1KMT2ATDP1 | |
| SCHEMBL27560000 | 0.82 | MAP2K1 (0.64) | MAP2K1MAP2K2MEN1KMT2ATDP1 | |
| SCHEMBL7715687 | 0.81 | MAP2K1 (0.56) | MAP2K1MAP2K2MEN1KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1383823-A | Methods of treating or inhibiting neutrophil chemotaxis by administering MEK inhibitors | WARNER LAMBERT CO (US) | 2002-12-11 | — | — | CN | claimed |
| CN-1373660-A | Method for treating chronic pain using MEK inhibitors | WARNER LAMBERT CO (US) | 2002-10-09 | — | — | CN | claimed |
| CN-1383823-A | Methods of treating or inhibiting neutrophil chemotaxis by administering MEK inhibitors | WARNER LAMBERT CO (US) | 2002-12-11 | — | — | CN | disclosed |