Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.51 |
| ▸ | GNAO1 | P09471 | 6/20 | 0.42 |
| ▸ | GNAI3 | P08754 | 5/20 | 0.42 |
| ▸ | GNAI1 | P63096 | 5/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | GLB1 | P16278 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19662033 | 0.82 | HRH3 (0.43) | HRH3CHRM3 | |
| SCHEMBL30669405 | 0.79 | GNAO1 (0.50) | GNAO1GNAI3GNAI1CHRM3 | |
| SCHEMBL11468832 | 0.77 | GUSB (0.49) | GNAO1GNAI3GNAI1GLB1 | |
| SCHEMBL11460694 | 0.77 | GUSB (0.49) | GNAO1GNAI3GNAI1GLB1 | |
| SCHEMBL11466227 | 0.77 | GUSB (0.49) | GNAO1GNAI3GNAI1GLB1 | |
| SCHEMBL12064339 | 0.76 | GNAO1 (0.48) | GNAO1GNAI3GNAI1CHRM3MAOA | |
| SCHEMBL1928295 | 0.75 | CYP2D6 (0.46) | HRH3CHRM3CYP2D6 | |
| SCHEMBL13085773 | 0.75 | HRH3 (0.39) | HRH3CHRM3CYP2D6 | |
| SCHEMBL12464727 | 0.74 | GNAO1 (0.47) | GNAO1GNAI3GNAI1CHRM3MAOA | |
| SCHEMBL28833655 | 0.74 | HRH3 (0.40) | HRH3CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100345833-C | Modulators of dopamine neurotransmission | CARLSSON RES AB (SE) | 2007-10-31 | — | — | CN | disclosed |
| CN-1255382-C | Novel modulators of dopamine neurotransmission | CARLSSON A RESEARCH AB (SE) | 2006-05-10 | — | — | CN | disclosed |
| CN-1765890-A | Modulators of dopamine neurotransmission | CARLSSON RES AB (SE) | 2006-05-03 | — | — | CN | disclosed |
| CN-1420869-A | Novel modulators of dopamine neurotransmission | CARLSSON A RESEARCH AB (SE) | 2003-05-28 | — | — | CN | disclosed |