Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3CHRM1CHRM2CHRM3CHRM4ESR1ESR2GABRA1GABRB1GABRG2GBA1HRH1HTR1DHTR2AOPRD1OPRK1OPRM1SLC6A2SLC6A3TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8rplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Cadaverine Tartrate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.45 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.45 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.45 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.45 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cadaverine Tartrate SCHEMBL3721240 | 0.89 | FFAR1 (0.56) | TDP1KDM4EKEAP1CYP1A2HDAC2 | |
| Phenylethyl Alcohol SCHEMBL21905692 | 0.86 | TDP1 (0.64) | TDP1KDM4EKEAP1CYP1A2SMN1; SMN2 | |
| Phenylethyl Alcohol SCHEMBL27469707 | 0.83 | TDP1 (0.67) | TDP1KDM4EKEAP1CYP1A2HDAC2 | |
| Phenylethyl Alcohol SCHEMBL8968173 | 0.82 | TDP1 (1.00) | TDP1KEAP1HDAC2HDAC8HDAC6 | |
| Phenylethyl Alcohol SCHEMBL1867158 | 0.82 | TDP1 (1.00) | TDP1KEAP1HDAC2HDAC8HDAC6 | |
| Phenylethyl Alcohol SCHEMBL1838 | 0.82 | — | — | |
| Phenylethyl Alcohol SCHEMBL28820852 | 0.82 | TDP1 (1.00) | TDP1KEAP1HDAC2HDAC8HDAC6 | |
| Phenylethyl Alcohol SCHEMBL11450063 | 0.82 | TDP1 (1.00) | TDP1KEAP1HDAC2HDAC8HDAC6 | |
| Phenylethyl Alcohol SCHEMBL27927126 | 0.82 | TDP1 (1.00) | TDP1KEAP1HDAC2HDAC8HDAC6 | |
| Cadaverine Tartrate SCHEMBL31121656 | 0.82 | HTR2A (0.64) | KDM4EKEAP1CYP1A2HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1218463-A | Novel method for asymmetric synthesis of R-alpha-propyl-piperonyl amine and analogues thereof | PONT PHARMACEUTICAL CO DU (US) | 1999-06-02 | — | — | CN | disclosed |