Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.46 |
| ▸ | SCN9A | Q15858 | 8/20 | 0.38 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.38 |
| ▸ | KIF11 | P52732 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | GLA | P06280 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | CASP7 | P55210 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27382005 | 0.83 | BRD4 (0.44) | BRD4CREBBPSCN9ASCN5AKDM4E | |
| SCHEMBL7499261 | 0.81 | GSK3B (0.51) | BRD4CREBBP | |
| SCHEMBL27466047 | 0.77 | SCARB1 (0.46) | BRD4CREBBPSCN9AEGFRMAPT | |
| SCHEMBL27405210 | 0.76 | BRD4 (0.42) | BRD4CREBBPSCN9AEGFRGAA | |
| SCHEMBL13806241 | 0.74 | KDM4E (0.51) | BRD4CREBBPKIF11GAAMAPT | |
| SCHEMBL146859 | 0.73 | SCN9A (0.66) | BRD4CREBBPSCN9ASCN5AEGFR | |
| SCHEMBL147558 | 0.71 | IDO1 (0.58) | BRD4CREBBPSCN9ASCN5A | |
| SCHEMBL17680562 | 0.70 | NR4A2 (0.45) | BRD4CREBBPSCN9AKIF11GAA | |
| SCHEMBL31632856 | 0.70 | SCN9A (0.56) | BRD4CREBBPSCN9ASCN5AKIF11 | |
| SCHEMBL31556362 | 0.69 | MAPT (0.45) | BRD4CREBBPSCN9ASCN5AKIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1226248-A | Substituted bisindolylmaleimides for inhibition of cell proliferation | HOFFMANN LA ROCHE (CH) | 1999-08-18 | — | — | CN | disclosed |