Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.44 |
| ▸ | ELANE | P08246 | 5/20 | 0.41 |
| ▸ | F2 | P00734 | 3/20 | 0.41 |
| ▸ | PLAU | P00749 | 3/20 | 0.41 |
| ▸ | CTRB1 | P17538 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27515744 | 0.83 | BRD4 (0.46) | BRD4CREBBPKMT2AKDM4ESCN5A | |
| SCHEMBL7501375 | 0.83 | BRD4 (0.47) | BRD4CREBBPCDK2 | |
| SCHEMBL27466047 | 0.73 | SCARB1 (0.46) | BRD4CREBBPMEN1KMT2AKDM4E | |
| SCHEMBL146859 | 0.70 | SCN9A (0.66) | BRD4CREBBPSCN5ASCN9A | |
| SCHEMBL147558 | 0.68 | IDO1 (0.58) | BRD4CREBBPSCN5ASCN9A | |
| SCHEMBL17680562 | 0.68 | NR4A2 (0.45) | BRD4CREBBPKDM4ESCN9A | |
| SCHEMBL668748 | 0.67 | CCNE2 (0.57) | CDK2 | |
| SCHEMBL29263665 | 0.67 | NR4A2 (0.59) | ELANEF2PLAUCTRB1POLB | |
| SCHEMBL31632856 | 0.67 | SCN9A (0.56) | BRD4CREBBPKMT2AKDM4ESCN5A | |
| SCHEMBL15712172 | 0.67 | L3MBTL1 (0.51) | BRD4POLBMEN1KMT2ASCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1077571-C | Substituted bisindolylmaleimides for inhibiting cell proliferation | HOFFMANN LA ROCHE (CH) | 2002-01-09 | — | — | CN | disclosed |