Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | MGLL | Q99685 | 2/20 | 0.57 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | KDM1A | O60341 | 2/20 | 0.51 |
| ▸ | MAOA | P21397 | 2/20 | 0.51 |
| ▸ | MAOB | P27338 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | KDR | P35968 | 1/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.50 |
| ▸ | FAAH | O00519 | 1/20 | 0.50 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10595799 | 0.89 | POLB (0.73) | POLBMGLLLMNAMAPTTP53 | |
| Benzyl Phenylcarbamate SCHEMBL1222943 | 0.85 | POLB (0.78) | POLBMGLLLMNAMAPTTP53 | |
| SCHEMBL4879147 | 0.84 | POLB (0.59) | POLBMGLLRAD51LMNAMAPT | |
| SCHEMBL4879134 | 0.84 | POLB (0.59) | POLBMGLLRAD51LMNAMAPT | |
| SCHEMBL4879614 | 0.83 | POLB (0.58) | POLBMGLLRAD51LMNAMAPT | |
| SCHEMBL4879623 | 0.83 | POLB (0.58) | POLBMGLLRAD51LMNAMAPT | |
| SCHEMBL4089550 | 0.82 | POLB (0.64) | POLBMGLLMAPTTP53ENPP2 | |
| SCHEMBL20975507 | 0.81 | POLB (0.63) | POLBMGLLLMNAMAPTTP53 | |
| SCHEMBL4678478 | 0.81 | MGLL (0.71) | POLBMGLLLMNAMAPTTP53 | |
| SCHEMBL10494592 | 0.81 | POLB (0.68) | POLBMGLLMAPTTP53ENPP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1241909-C | Carboxylic acid derivatives as IP antagonists | HOFFMANN LA ROCHE (CH) | 2006-02-15 | — | — | CN | disclosed |
| CN-1418187-A | Carboxylic acid derivatives as IP antagonists | HOFFMANN LA ROCHE (CH) | 2003-05-14 | — | — | CN | disclosed |