Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 9/20 | 0.53 |
| ▸ | F10 | P00742 | 9/20 | 0.53 |
| ▸ | PRSS1 | P07477 | 9/20 | 0.53 |
| ▸ | PRSS2 | P07478 | 9/20 | 0.53 |
| ▸ | PRSS3 | P35030 | 9/20 | 0.53 |
| ▸ | KLKB1 | P03952 | 11/20 | 0.51 |
| ▸ | F9 | P00740 | 2/20 | 0.51 |
| ▸ | PROC | P04070 | 2/20 | 0.51 |
| ▸ | KLK1 | P06870 | 1/20 | 0.51 |
| ▸ | CFH | P08603 | 1/20 | 0.50 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27519261 | 0.88 | F2 (0.58) | F2F10PRSS1PRSS2PRSS3 | |
| SCHEMBL27499211 | 0.87 | F2 (0.57) | F2F10PRSS1PRSS2PRSS3 | |
| SCHEMBL27499212 | 0.86 | F2 (0.56) | F2F10PRSS1PRSS2PRSS3 | |
| SCHEMBL31678809 | 0.85 | KLKB1 (0.70) | F2F10PRSS1PRSS2PRSS3 | |
| SCHEMBL27536938 | 0.85 | KLKB1 (0.70) | F2F10PRSS1PRSS2PRSS3 | |
| SCHEMBL29286937 | 0.82 | KLKB1 (0.58) | F2F10PRSS1PRSS2PRSS3 | |
| SCHEMBL29286939 | 0.82 | F10 (0.58) | F2F10PRSS1PRSS2PRSS3 | |
| SCHEMBL27500723 | 0.79 | F10 (0.57) | F2F10PRSS1PRSS2PRSS3 | |
| SCHEMBL27501129 | 0.74 | KLKB1 (0.57) | F2F10PRSS1PRSS2PRSS3 | |
| Trifluoroacetic Acid SCHEMBL27498912 | 0.71 | F10 (0.38) | F2F10PRSS1PRSS2PRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1246847-A | Nitrogen containing heteroaromatics as factor Xa inhibitors | DU PONT MERCK PHARMA (US) | 2000-03-08 | — | — | CN | claimed |
| CN-1246847-A | Nitrogen containing heteroaromatics as factor Xa inhibitors | DU PONT MERCK PHARMA (US) | 2000-03-08 | — | — | CN | disclosed |