Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 7/20 | 0.58 |
| ▸ | CYP11B1 | P15538 | 6/20 | 0.52 |
| ▸ | CYP11B2 | P19099 | 6/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6124253 | 0.85 | NOTUM (0.65) | NOTUMCYP11B1CYP11B2RAB9AALDH1A1 | |
| SCHEMBL8567499 | 0.84 | CYP11B1 (0.65) | NOTUMCYP11B1CYP11B2RAB9AALDH1A1 | |
| SCHEMBL27536609 | 0.83 | NOTUM (0.61) | NOTUMCYP11B1CYP11B2RAB9AALDH1A1 | |
| SCHEMBL8803741 | 0.82 | NOTUM (0.60) | NOTUMCYP11B1CYP11B2RAB9AALDH1A1 | |
| SCHEMBL27876300 | 0.82 | NOTUM (0.53) | NOTUMCYP11B1CYP11B2RAB9AALDH1A1 | |
| SCHEMBL15743832 | 0.80 | NOTUM (0.61) | NOTUMCYP11B1CYP11B2RAB9AALDH1A1 | |
| SCHEMBL14663963 | 0.78 | NOTUM (0.58) | NOTUMCYP11B1CYP11B2RAB9AALDH1A1 | |
| SCHEMBL14665068 | 0.78 | NOTUM (0.58) | NOTUMCYP11B1CYP11B2RAB9AALDH1A1 | |
| SCHEMBL13711475 | 0.77 | PDK1 (0.64) | NOTUMALDH1A1TRIM24TP53SMN1; SMN2 | |
| SCHEMBL16508643 | 0.77 | NOTUM (0.57) | NOTUMCYP11B1CYP11B2RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1252070-A | 5,7-disubstituted 4-aminopyrido [2,3,-d] pyrimidine compounds and their use as adenosine kinase inhibitors | ABBOTT LAB (US) | 2000-05-03 | — | — | CN | disclosed |