Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | PRKDC | P78527 | 1/20 | 0.49 |
| ▸ | GSK3B | P49841 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 6/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5217432 | 0.88 | ALDH1A1 (0.55) | ALDH1A1LMNAHIF1ATSHRPRKDC | |
| SCHEMBL5217443 | 0.88 | ALDH1A1 (0.55) | ALDH1A1LMNAHIF1ATSHRPRKDC | |
| SCHEMBL2444961 | 0.87 | HIF1A (0.55) | ALDH1A1LMNAHIF1ATSHRPRKDC | |
| SCHEMBL28745217 | 0.86 | MAPT (0.54) | ALDH1A1LMNAHIF1ATSHRMAPT | |
| SCHEMBL27565323 | 0.84 | ALDH1A1 (0.53) | ALDH1A1LMNAHIF1ATSHRMAPT | |
| SCHEMBL28456821 | 0.84 | ALDH1A1 (0.51) | ALDH1A1LMNAHIF1ATSHRPRKDC | |
| SCHEMBL27741267 | 0.83 | NPC1 (0.51) | ALDH1A1LMNAMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL8546835 | 0.80 | ALDH1A1 (0.52) | ALDH1A1LMNAHIF1APRKDCGSK3B | |
| SCHEMBL28780196 | 0.80 | GFER (0.61) | ALDH1A1LMNATSHRMAPTMAPK1 | |
| SCHEMBL2627852 | 0.80 | ALDH1A1 (0.67) | ALDH1A1LMNAHIF1AMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1252070-A | 5,7-disubstituted 4-aminopyrido [2,3,-d] pyrimidine compounds and their use as adenosine kinase inhibitors | ABBOTT LAB (US) | 2000-05-03 | — | — | CN | disclosed |