Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHBP | P24387 | 1/20 | 0.50 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 7/20 | 0.49 |
| ▸ | MGLL | Q99685 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6159335 | 0.75 | MAPT (0.65) | MAPTSMN1; SMN2MEN1NPC1LMNA | |
| SCHEMBL27597238 | 0.71 | TRPV1 (0.48) | CRHBPCRHR2MAPTSMN1; SMN2MEN1 | |
| SCHEMBL27517851 | 0.70 | PTGS1 (0.54) | MAPTSMN1; SMN2GAAPOLB | |
| SCHEMBL27700481 | 0.70 | PTGS1 (0.54) | MAPTSMN1; SMN2GAAPOLB | |
| SCHEMBL30665998 | 0.69 | MAPT (0.60) | CRHBPCRHR2MAPTSMN1; SMN2MEN1 | |
| SCHEMBL1169369 | 0.69 | MAPT (0.60) | CRHBPCRHR2MAPTSMN1; SMN2MEN1 | |
| SCHEMBL14750964 | 0.68 | MAPT (0.51) | MAPTSMN1; SMN2MEN1KMT2AGAA | |
| SCHEMBL7270186 | 0.67 | ALDH1A1 (0.68) | MAPTSMN1; SMN2MEN1LMNAMAPK1 | |
| SCHEMBL7261751 | 0.67 | PTGS1 (0.65) | SMN1; SMN2GAAPOLB | |
| SCHEMBL31474894 | 0.66 | MAPT (0.56) | CRHBPCRHR2MAPTSMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1267423-C | Substituted 2-phenylaminoimidazolinylphenyl ketone derivatives as IP antagonists | HOFFMANN LA ROCHE (CH) | 2006-08-02 | — | — | CN | disclosed |