Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | AKT2 | P31751 | 1/20 | 0.43 |
| ▸ | KMO | O15229 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | FTO | Q9C0B1 | 2/20 | 0.41 |
| ▸ | KDM5A | P29375 | 2/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.41 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.41 |
| ▸ | KDM6B | O15054 | 1/20 | 0.41 |
| ▸ | TET3 | O43151 | 1/20 | 0.41 |
| ▸ | KDM4A | O75164 | 1/20 | 0.41 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KDM5C | P41229 | 1/20 | 0.41 |
| ▸ | ASPH | Q12797 | 1/20 | 0.41 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.41 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.41 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.41 |
| ▸ | KDM7A | Q6ZMT4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5258336 | 0.91 | CHEK1 (0.42) | CHEK1AKT2KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL5255455 | 0.90 | FYN (0.45) | CHEK1AKT2KDM4EALDH1A1MAPK1 | |
| SCHEMBL27544001 | 0.87 | CHEK1 (0.39) | CHEK1AKT2KDM4EALDH1A1MAPT | |
| SCHEMBL5257418 | 0.87 | NPC1 (0.44) | CHEK1AKT2KDM4EALDH1A1MAPT | |
| SCHEMBL5260432 | 0.83 | CHEK1 (0.47) | CHEK1AKT2KDM4EALDH1A1MAPK1 | |
| SCHEMBL27540780 | 0.82 | CHEK1 (0.39) | CHEK1AKT2KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL27540778 | 0.81 | CHEK1 (0.38) | CHEK1AKT2KDM4EALDH1A1MAPT | |
| SCHEMBL5255250 | 0.79 | CDC7 (0.47) | KMOFYN | |
| SCHEMBL5259330 | 0.78 | MAT2A (0.44) | CHEK1AKT2MAPK1NPSR1 | |
| SCHEMBL27540538 | 0.78 | ADORA2A (0.45) | CHEK1AKT2KDM4EALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1342157-A | Substituted pyrazoles ASP38 kinase inhibitors | SEARLE & CO (US) | 2002-03-27 | — | — | CN | disclosed |
| CN-1264377-A | Substituted pyrazoles as P38 kinase inhabitors | SEARLE & CO (US) | 2000-08-23 | — | — | CN | disclosed |