Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 18/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | GCGR | P47871 | 3/20 | 0.44 |
| ▸ | MAPK13 | O15264 | 5/20 | 0.43 |
| ▸ | MAPK12 | P53778 | 5/20 | 0.43 |
| ▸ | MAPK11 | Q15759 | 5/20 | 0.43 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.43 |
| ▸ | RAF1 | P04049 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.41 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27540879 | 0.82 | MAPK14 (0.52) | MAPK14GCGRMAPK13MAPK12MAPK11 | |
| Hydrochloric Acid SCHEMBL5850392 | 0.81 | MAPK14 (0.51) | MAPK14GCGRMAPK13MAPK12MAPK11 | |
| SCHEMBL27564368 | 0.79 | MAPK14 (0.43) | MAPK14GCGRMAPK13MAPK12MAPK11 | |
| SCHEMBL5849702 | 0.79 | MAPK14 (0.54) | MAPK14GCGRMAPK13MAPK12MAPK11 | |
| SCHEMBL5850129 | 0.77 | MAPK14 (0.48) | MAPK14GCGRMAPK13MAPK12MAPK11 | |
| SCHEMBL5850311 | 0.76 | MAPK14 (0.47) | MAPK14GCGRMAPK13MAPK12MAPK11 | |
| SCHEMBL5849797 | 0.75 | MAPK14 (0.49) | MAPK14GCGRMAPK13MAPK12MAPK11 | |
| SCHEMBL5850546 | 0.74 | MPO (0.48) | MAPK14GCGRMAPK13MAPK12MAPK11 | |
| SCHEMBL5849830 | 0.74 | MPO (0.48) | MAPK14HTR2CGCGRMAPK13MAPK12 | |
| SCHEMBL5850062 | 0.74 | MPO (0.48) | MAPK14GCGRMAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1294129-C | Heteraryl-substituted porrole derivatives, their prep. and therapeutic use | SANKYO CO (JP) | 2007-01-10 | — | — | CN | disclosed |
| CN-1295069-A | Heteraryl-substituted porrole derivatives, their prep. and therapeutic use | SANKYO CO (JP) | 2001-05-16 | — | — | CN | disclosed |