Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 14/20 | 0.51 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ALPL | P05186 | 1/20 | 0.34 |
| ▸ | ALPI | P09923 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27516110 | 0.87 | LSS (0.39) | LSSCA12CA2HPGDKDM4E | |
| SCHEMBL5043268 | 0.85 | LSS (0.47) | LSSCA2 | |
| SCHEMBL27544469 | 0.84 | KIF11 (0.41) | LSSCA12CA2HPGDALDH1A1 | |
| SCHEMBL8484965 | 0.82 | LSS (0.56) | LSS | |
| SCHEMBL8481582 | 0.77 | LSS (0.55) | LSS | |
| SCHEMBL5035587 | 0.77 | LSS (0.59) | LSSHPGDKDM4EALDH1A1 | |
| SCHEMBL5043364 | 0.76 | LSS (0.58) | LSS | |
| SCHEMBL3981917 | 0.76 | LSS (0.71) | LSS | |
| SCHEMBL5038691 | 0.75 | LSS (0.66) | LSS | |
| SCHEMBL5040449 | 0.75 | LSS (0.57) | LSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1261429-C | Cholesterol lowering benzo [ b ] thiophenes and benzo [ d ] isothiazoles | HOFFMANN LA ROCHE (CH) | 2006-06-28 | — | — | CN | disclosed |
| CN-1471522-A | Cholesterol lowering benzo [b] thiophenes and benzo[d] isothiazoles | - | 2004-01-28 | — | — | CN | disclosed |